Isocitrate dehydrogenase [NADP], mitochondrial
Also known as: IDH2
Function
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
Classification
- Family (Pfam)
- PF00180 Iso_dh
- InterPro
- IsoCit/isopropylmalate_DH_CS, Isocitrate_DH_NADP, IsoPropMal-DH-like_dom
- Functional cluster
- Oxidoreductases & Polyketide Synthases
Experimental structures · PDB · 11
- 4JA8 X-ray 1.55A
- 5GIS X-ray 1.93A
- 5I95 X-ray 1.54A
- 5I96 X-ray 1.55A
- 5SVN X-ray 2.10A
- 5SVO X-ray 1.87A
- 6ADI X-ray 1.97A
- 6UJ7 X-ray 1.90A
- 6UJ8 X-ray 2.25A
- 6UJ9 X-ray 2.90A
- 6VFZ X-ray 1.99A
A predicted model is available from AlphaFold.
Gene Ontology · 18
- GO:0005829 cytosol
- GO:0070062 extracellular exosome
- GO:0005759 mitochondrial matrix
- GO:0005739 mitochondrion
- GO:0005777 peroxisome
- GO:0004450 isocitrate dehydrogenase (NADP+) activity
- GO:0000287 magnesium ion binding
- GO:0051287 NAD binding
- GO:0006103 2-oxoglutarate metabolic process
- GO:0005975 carbohydrate metabolic process
- GO:0006097 glyoxylate cycle
- GO:0006102 isocitrate metabolic process
- GO:0006741 NADP+ biosynthetic process
- GO:0006739 NADP+ metabolic process
- GO:1903976 negative regulation of glial cell migration
- GO:0060253 negative regulation of glial cell proliferation
- GO:1904465 negative regulation of matrix metallopeptidase secretion
- GO:0006099 tricarboxylic acid cycle
Disease associations
- glioma susceptibility 1 MONDO:0024498
- d-2-hydroxyglutaric aciduria 2 MONDO:0013345
Drugs targeting this protein · 3
- ENASIDENIB MESYLATE inhibitor
- VORASIDENIB inhibitor
- VORASIDENIB CITRATE inhibitor
Related proteins · sequence + function similarity
- Isocitrate dehydrogenase [NADP], mitochondrial 1.00
- Isocitrate dehydrogenase [NADP], mitochondrial 0.99
- Isocitrate dehydrogenase [NADP], mitochondrial 0.99
- Isocitrate dehydrogenase [NADP], mitochondrial 0.99
- Isocitrate dehydrogenase [NADP], mitochondrial 0.95
- Probable isocitrate dehydrogenase [NADP], mitochondrial 0.89
- Isocitrate dehydrogenase [NADP] cytoplasmic 0.87
- Isocitrate dehydrogenase [NADP] cytoplasmic 0.87
- Isocitrate dehydrogenase [NADP] cytoplasmic 0.87
- Isocitrate dehydrogenase [NADP] cytoplasmic 0.87
- Isocitrate dehydrogenase [NADP] cytoplasmic 0.86
- Isocitrate dehydrogenase [NADP] cytoplasmic 0.86
Co-cited proteins · studied together in the literature
- Isocitrate dehydrogenase [NADP] cytoplasmic 1 shared papers
Literature · 12 cited papers
- Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. PLoS ONE · 2015
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- IDH2 mutation in gliomas including novel mutation. Neuropathology · 2015
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J. Biol. Chem. · 2012
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- IDH2 mutations in patients with D-2-hydroxyglutaric aciduria. Science · 2010
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
- IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. · 2009
- Analysis of the DNA sequence and duplication history of human chromosome 15. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
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