Isocitrate dehydrogenase [NADP] cytoplasmic

UniProt O75874 Organism Homo sapiens Gene IDH1, PICD EC 1.1.1.42

Also known as: IDH1, PICD

Function

Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase. Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways. May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity).

Classification

Family (Pfam): PF00180 Iso_dh
InterPro: IsoCit/isopropylmalate_DH_CS, Isocitrate_DH_NADP, IsoPropMal-DH-like_dom
Functional cluster: RuBisCO & Carbon-Fixation Enzymes

Experimental structures · PDB · 58

1T09 X-ray 2.70A
1T0L X-ray 2.41A
3INM X-ray 2.10A
3MAP X-ray 2.80A
3MAR X-ray 3.41A
3MAS X-ray 3.20A
4I3K X-ray 3.31A
4I3L X-ray 3.29A
4KZO X-ray 2.20A
4L03 X-ray 2.10A
4L04 X-ray 2.87A
4L06 X-ray 2.28A
… and 46 more

A predicted model is available from AlphaFold.

Gene Ontology · 25

Disease associations

glioma susceptibility 1 MONDO:0024498

Drugs targeting this protein · 7

IVOSIDENIB inhibitor
IDH305 inhibitor
BAY1436032 inhibitor
VORASIDENIB inhibitor
OLUTASIDENIB inhibitor
VORASIDENIB CITRATE inhibitor
DS-1001B inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Isocitrate dehydrogenase [NADP] cytoplasmic 1 shared papers
Isocitrate dehydrogenase [NADP], mitochondrial 1 shared papers
Isocitrate dehydrogenase [NADP] cytoplasmic 1 shared papers
Isocitrate dehydrogenase [NADP] cytoplasmic 1 shared papers
Isocitrate dehydrogenase [NADP] cytoplasmic 1 shared papers

Literature · 17 cited papers

Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes. PLoS ONE · 2015
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature · 2009
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors. Hum. Mutat. · 2009
An integrated genomic analysis of human glioblastoma multiforme. Science · 2008
The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
The consensus coding sequences of human breast and colorectal cancers. Science · 2006
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
… and 5 more in the literature graph

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