G protein-activated inward rectifier potassium channel 1
Also known as: GIRK1, KCNJ3
Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins. This receptor plays a crucial role in regulating the heartbeat (By similarity).
Classification
- Family (Pfam)
- PF01007 IRK, PF17655 IRK_C
- InterPro
- Ig_E-set, IRK_C, K_chnl_inward-rec_Kir, K_chnl_inward-rec_Kir3.1, K_chnl_inward-rec_Kir_cyto, Kir_TM
- Functional cluster
- Nucleotide & Amino-Acid Biosynthesis Enzymes
Gene Ontology · 19
- GO:0009897 external side of plasma membrane
- GO:1902937 inward rectifier potassium channel complex
- GO:0098688 parallel fiber to Purkinje cell synapse
- GO:0005886 plasma membrane
- GO:0042734 presynaptic membrane
- GO:0030315 T-tubule
- GO:0008076 voltage-gated potassium channel complex
- GO:0015467 G-protein activated inward rectifier potassium channel activity
- GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
- GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
- GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
- GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
- GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential
- GO:1990573 potassium ion import across plasma membrane
- GO:0071805 potassium ion transmembrane transport
- GO:0006813 potassium ion transport
- GO:0086091 regulation of heart rate by cardiac conduction
- GO:0051602 response to electrical stimulus
- GO:0099625 ventricular cardiac muscle cell membrane repolarization
Drugs targeting this protein · 1
- VERNAKALANT HYDROCHLORIDE blocker
Related proteins · sequence + function similarity
- G protein-activated inward rectifier potassium channel 1 1.00
- G protein-activated inward rectifier potassium channel 1 1.00
- G protein-activated inward rectifier potassium channel 1 1.00
- G protein-activated inward rectifier potassium channel 1 0.99
- G protein-activated inward rectifier potassium channel 4 0.91
- G protein-activated inward rectifier potassium channel 2 0.90
- G protein-activated inward rectifier potassium channel 4 0.90
- G protein-activated inward rectifier potassium channel 2 0.90
- G protein-activated inward rectifier potassium channel 2 0.90
- G protein-activated inward rectifier potassium channel 2 0.90
- G protein-activated inward rectifier potassium channel 2 0.89
- G protein-activated inward rectifier potassium channel 4 0.89
Co-cited proteins · studied together in the literature
- G protein-activated inward rectifier potassium channel 4 2 shared papers
- ATP-sensitive inward rectifier potassium channel 1 1 shared papers
- G protein-activated inward rectifier potassium channel 3 1 shared papers
- G protein-activated inward rectifier potassium channel 2 1 shared papers
- ATP-sensitive inward rectifier potassium channel 10 1 shared papers
Literature · 7 cited papers
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function. J. Biol. Chem. · 2000
- Co-expression of human Kir3 subunits can yield channels with different functional properties. Cell. Signal. · 1999
- A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. J. Gen. Physiol. · 1996
- Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum. Brain Res. Mol. Brain Res. · 1996
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