G protein-activated inward rectifier potassium channel 4

UniProt P48544 Organism Homo sapiens Gene GIRK4, KCNJ5

Also known as: GIRK4, KCNJ5

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. This potassium channel is controlled by G proteins.

Classification

Family (Pfam): PF01007 IRK, PF17655 IRK_C
InterPro: Ig_E-set, IRK_C, K_chnl_inward-rec_Kir, K_chnl_inward-rec_Kir3.4, K_chnl_inward-rec_Kir_cyto, Kir_TM
Functional cluster: Nucleotide & Amino-Acid Biosynthesis Enzymes

Gene Ontology · 13

Disease associations

long QT syndrome 13 MONDO:0013279
familial hyperaldosteronism type III MONDO:0013359

Drugs targeting this protein · 1

VERNAKALANT HYDROCHLORIDE blocker

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

G protein-activated inward rectifier potassium channel 4 3 shared papers
G protein-activated inward rectifier potassium channel 1 2 shared papers
G protein-activated inward rectifier potassium channel 4 1 shared papers
G protein-activated inward rectifier potassium channel 3 1 shared papers
G protein-activated inward rectifier potassium channel 2 1 shared papers
ATP-sensitive inward rectifier potassium channel 10 1 shared papers

Literature · 20 cited papers

Functional characterization of two novel germline mutations of the KCNJ5 gene in hypertensive patients without primary aldosteronism but with ACTH-dependent aldosterone hypersecretion. Clin. Endocrinol. (Oxf.) · 2016
Mutated KCNJ5 activates the acute and chronic regulatory steps in aldosterone production. J. Mol. Endocrinol. · 2016
a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III. J. Clin. Endocrinol. Metab. · 2013
Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter. PLoS ONE · 2012
A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension. J. Clin. Endocrinol. Metab. · 2012
Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Endocrinology · 2012
Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5. Proc. Natl. Acad. Sci. U.S.A. · 2012
Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism. Hypertension · 2012
KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism. Hypertension · 2012
K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science · 2011
Identification of a Kir3.4 mutation in congenital long QT syndrome. Am. J. Hum. Genet. · 2010
Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
… and 8 more in the literature graph

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