lmmol · Proteins

Neuronal acetylcholine receptor subunit alpha-4

UniProt P43681 Organism Homo sapiens Gene CHRNA4, NACRA4

Also known as: CHRNA4, NACRA4

Function

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA4 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4, as well as CHRNA5 and CHRNB3 as accesory subunits. Is the most abundant nAChR subtype expressed in the central nervous system. Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation. Involved in the modulation of calcium-dependent signaling pathways, influences the release of neurotransmitters, including dopamine, glutamate and GABA (By similarity).

Classification

Family (Pfam)
PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
InterPro
Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS, Nicotinic_acetylcholine_rcpt
Functional cluster
Cytochrome P450 & Heme Enzymes

Experimental structures · PDB · 12

A predicted model is available from AlphaFold.

Gene Ontology · 40

Disease associations

Drugs targeting this protein · 15

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 19 cited papers

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