Neuronal acetylcholine receptor subunit alpha-5

UniProt P30532 Organism Homo sapiens Gene CHRNA5, NACHRA5

Also known as: CHRNA5, NACHRA5

Function

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNB2 and CHRNB4. Increases receptor sensitivity to acetylcholine and nicotine when associated with CHRNA4 and CHRNB2. Plays a role in nicotine addiction.

Classification

Family (Pfam): PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
InterPro: Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS, Nicotinic_acetylcholine_rcpt
Functional cluster: Cytochrome P450 & Heme Enzymes

Gene Ontology · 23

Disease associations

OMIM:612052 RAW:OMIM_612052

Drugs targeting this protein · 1

POZANICLINE partial agonist

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Neuronal acetylcholine receptor subunit alpha-3 8 shared papers
Neuronal acetylcholine receptor subunit beta-4 5 shared papers
Neuronal acetylcholine receptor subunit beta-2 5 shared papers
Neuronal acetylcholine receptor subunit alpha-4 4 shared papers
Neuronal acetylcholine receptor subunit beta-3 2 shared papers
Neuronal acetylcholine receptor subunit alpha-6 2 shared papers
Neuronal acetylcholine receptor subunit alpha-7 3 shared papers
Ly6/PLAUR domain-containing protein 6 1 shared papers
Neuronal acetylcholine receptor subunit alpha-2 1 shared papers
Ly6/PLAUR domain-containing protein 6 1 shared papers

Literature · 10 cited papers

Functional interaction between Lypd6 and nicotinic acetylcholine receptors. J. Neurochem. · 2016
Acetylcholine receptor (AChR) alpha5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (alpha4beta2)(2)alpha5 AChR function. Mol. Pharmacol. · 2011
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature · 2008
Genomics: when the smoke clears. Nature · 2008
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat. Genet. · 2008
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. FEBS Lett. · 1997
Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. J. Mol. Neurosci. · 1996
Assembly of human neuronal nicotinic receptor alpha5 subunits with alpha3, beta2, and beta4 subunits. J. Biol. Chem. · 1996
Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines. Proc. Natl. Acad. Sci. U.S.A. · 1992

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