Glycerol-3-phosphate dehydrogenase, mitochondrial
Also known as: GPD2
Function
Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.
Classification
- Family (Pfam)
- PF01266 DAO, PF16901 DAO_C, PF13499 EF-hand_7
- InterPro
- DAO_C, DAO_C_sf, EF-hand-dom_pair, EF_Hand_1_Ca_BS, EF_hand_dom, FAD-dep_OxRdtase, FAD/NAD-bd_sf, G3P_DH_FAD-dep
- Functional cluster
- Oxidoreductases & Polyketide Synthases
Gene Ontology · 7
Drugs targeting this protein · 1
- METFORMIN HYDROCHLORIDE inhibitor
Related proteins · sequence + function similarity
- Glycerol-3-phosphate dehydrogenase, mitochondrial 1.00
- Glycerol-3-phosphate dehydrogenase, mitochondrial 0.99
- Glycerol-3-phosphate dehydrogenase, mitochondrial 0.98
- Glycerol-3-phosphate dehydrogenase, mitochondrial 0.97
- Glycerol-3-phosphate dehydrogenase, mitochondrial 0.97
- Probable glycerol-3-phosphate dehydrogenase, mitochondrial 0.94
- Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial 0.85
- Glycerol-3-phosphate dehydrogenase, mitochondrial 0.82
- Glycerol-3-phosphate dehydrogenase, mitochondrial 0.74
- Probable glycerol-3-phosphate dehydrogenase, mitochondrial 0.72
- L-2-hydroxyglutarate dehydrogenase, mitochondrial 0.66
- Glycerol-3-phosphate dehydrogenase 2 0.61
Co-cited proteins · studied together in the literature
- ATP synthase subunit s, mitochondrial 1 shared papers
- Deoxyhypusine synthase 1 shared papers
- Protein FAM216A 1 shared papers
- Protein FAM13C 1 shared papers
- Coiled-coil domain-containing protein 106 1 shared papers
- SAC3 domain-containing protein 1 1 shared papers
- Interleukin-15 receptor subunit alpha 1 shared papers
- Low-density lipoprotein receptor-related protein 10 1 shared papers
- Protein FAM110B 1 shared papers
- Transcription factor Gibbin 1 shared papers
- Peptidyl-glycine alpha-amidating monooxygenase 1 shared papers
- Bifunctional FAD diphosphatase/FAD synthase 1 shared papers
Literature · 9 cited papers
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Large-scale concatenation cDNA sequencing. Genome Res. · 1997
- Mutation in the calcium-binding domain of the mitochondrial glycerophosphate dehydrogenase gene in a family of diabetic subjects. Biochem. Biophys. Res. Commun. · 1997
- Structural organization and mapping of the human mitochondrial glycerol phosphate dehydrogenase-encoding gene and pseudogene. Gene · 1996
- Mitochondrial glycerol-3-phosphate dehydrogenase. Cloning of an alternatively spliced human islet-cell cDNA, tissue distribution, physical mapping, and identification of a polymorphic genetic marker. Diabetes · 1996
- The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA. Gene · 1994
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