Acetylcholinesterase 1
Also known as: ace-1
Function
Rapidly hydrolyzes acetylcholine and releases choline into the synapse (Probable). It can hydrolyze propionylcholine and butyrylthiocholine in vitro (Probable).
Classification
- Family (Pfam)
- PF00135 COesterase
- InterPro
- AB_hydrolase_fold, AChE-related_enzymes, CarbesteraseB, Carboxylesterase_B_AS, Carboxylesterase_B_CS, Cholinesterase
- Functional cluster
- Secreted Hydrolases & Toxins
Gene Ontology · 10
- GO:0005615 extracellular space
- GO:0005886 plasma membrane
- GO:0045202 synapse
- GO:0043083 synaptic cleft
- GO:0003990 acetylcholinesterase activity
- GO:0042802 identical protein binding
- GO:0006581 acetylcholine catabolic process
- GO:0001507 acetylcholine catabolic process in synaptic cleft
- GO:0019695 choline metabolic process
- GO:0040012 regulation of locomotion
Drugs targeting this protein · 1
- TRICHLORFON inhibitor
Related proteins · sequence + function similarity
- Acetylcholinesterase 1 0.99
- Acetylcholinesterase 0.90
- Cholinesterase 0.90
- Cholinesterase 0.90
- Acetylcholinesterase 0.90
- Cholinesterase 0.89
- Cholinesterase 0.89
- Cholinesterase 0.88
- Cholinesterase 0.87
- Acetylcholinesterase 0.87
- Cholinesterase 0.87
- Gut esterase 1 0.86
Literature · 3 cited papers
- Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins. Mol. Cell. Proteomics · 2007
- Genome sequence of the nematode C. elegans: a platform for investigating biology. Science · 1998
- cDNA sequence, gene structure, and in vitro expression of ace-1, the gene encoding acetylcholinesterase of class A in the nematode Caenorhabditis elegans. J. Biol. Chem. · 1994
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