Cholinesterase

Function

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.

Classification

Family (Pfam)

PF08674 AChE_tetra, PF00135 COesterase

InterPro

AB_hydrolase_fold, AChE-related_enzymes, AChE_tetra, CarbesteraseB, Carboxylesterase_B_AS, Carboxylesterase_B_CS, Cholinesterase

Functional cluster

Secreted Hydrolases & Toxins

Experimental structures · PDB · 106

• 1P0I X-ray 2.00A
• 1P0M X-ray 2.38A
• 1P0P X-ray 2.30A
• 1P0Q X-ray 2.43A
• 1XLU X-ray 2.20A
• 1XLV X-ray 2.25A
• 1XLW X-ray 2.10A
• 2J4C X-ray 2.75A
• 2PM8 X-ray 2.80A
• 2WID X-ray 2.30A
• 2WIF X-ray 2.25A
• 2WIG X-ray 2.15A
• … and 94 more

A predicted model is available from AlphaFold.

Gene Ontology · 26

• GO:0072562 blood microparticle
• GO:0005788 endoplasmic reticulum lumen
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005641 nuclear envelope lumen
• GO:0005886 plasma membrane
• GO:0003990 acetylcholinesterase activity
• GO:0001540 amyloid-beta binding
• GO:0003824 catalytic activity
• GO:0033265 choline binding
• GO:0004104 cholinesterase activity
• GO:0019899 enzyme binding
• GO:0016788 hydrolase activity, acting on ester bonds
• GO:0042802 identical protein binding
• GO:0006581 acetylcholine catabolic process
• GO:0019695 choline metabolic process
• GO:0050784 cocaine catabolic process
• GO:0007612 learning
• GO:0008285 negative regulation of cell population proliferation
• GO:0050805 negative regulation of synaptic transmission
• GO:0014016 neuroblast differentiation
• GO:0016486 peptide hormone processing
• GO:0043279 response to alkaloid
• GO:0051593 response to folic acid
• GO:0051384 response to glucocorticoid
• GO:0006805 xenobiotic metabolic process

Disease associations

• butyrylcholinesterase deficiency MONDO:0015270

Drugs targeting this protein · 4

• RIVASTIGMINE TARTRATE inhibitor
• TACRINE HYDROCHLORIDE inhibitor
• PROPANIDID inhibitor
• RIVASTIGMINE inhibitor

Related proteins · sequence + function similarity

• Cholinesterase 0.98
• Cholinesterase 0.98
• Cholinesterase 0.97
• Cholinesterase 0.97
• Cholinesterase 0.97
• Cholinesterase 0.95
• Acetylcholinesterase 0.91
• Acetylcholinesterase 0.91
• Acetylcholinesterase 0.90
• Acetylcholinesterase 0.90
• Acetylcholinesterase 1 0.89
• Acetylcholinesterase 4 0.88

Co-cited proteins · studied together in the literature

• Acetylcholinesterase 1 shared papers
• Fasciculin-2 1 shared papers

Literature · 48 cited papers

• Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), 'silent' with mivacurium. Biochem. Pharmacol. · 2014
• Characterization of a novel BCHE 'silent' allele: point mutation (p.Val204Asp) causes loss of activity and prolonged apnea with suxamethonium. PLoS ONE · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase. Biochem. J. · 2013
• Identification of phosphorylated butyrylcholinesterase in human plasma using immunoaffinity purification and mass spectrometry. Anal. Chim. Acta · 2012
• Biochemical, molecular and preclinical characterization of a double-virus-reduced human butyrylcholinesterase preparation designed for clinical use. Vox Sang. · 2011
• Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents. Mol. Pharmacol. · 2009
• The structure of G117H mutant of butyrylcholinesterase: nerve agents scavenger. Proteins · 2009
• Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. Biochem. J. · 2009
• Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
• A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol. Cell. Proteomics · 2009
• Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation. J. Am. Chem. Soc. · 2008
• … and 36 more in the literature graph