Acetylcholinesterase
Also known as: ACHE
Function
Hydrolyzes rapidly the acetylcholine neurotransmitter released into the synaptic cleft allowing to terminate the signal transduction at the neuromuscular junction. Role in neuronal apoptosis.
Classification
- Family (Pfam)
- PF08674 AChE_tetra, PF00135 COesterase
- InterPro
- AB_hydrolase_fold, AChE-related_enzymes, AChE_tetra, CarbesteraseB, Carboxylesterase_B_AS, Carboxylesterase_B_CS, Cholinesterase
- Functional cluster
- Secreted Growth Factors & Cytokines
Experimental structures · PDB · 79
- 1B41 X-ray 2.76A
- 1F8U X-ray 2.90A
- 1VZJ X-ray 2.35A
- 2X8B X-ray 2.95A
- 3LII X-ray 3.20A
- 4BDT X-ray 3.10A
- 4EY4 X-ray 2.16A
- 4EY5 X-ray 2.30A
- 4EY6 X-ray 2.40A
- 4EY7 X-ray 2.35A
- 4EY8 X-ray 2.60A
- 4M0E X-ray 2.00A
- … and 67 more
A predicted model is available from AlphaFold.
Gene Ontology · 32
- GO:0005604 basement membrane
- GO:0009986 cell surface
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:0005794 Golgi apparatus
- GO:0016020 membrane
- GO:0031594 neuromuscular junction
- GO:0005634 nucleus
- GO:0048471 perinuclear region of cytoplasm
- GO:0005886 plasma membrane
- GO:0098552 side of membrane
- GO:0045202 synapse
- GO:0043083 synaptic cleft
- GO:0042166 acetylcholine binding
- GO:0003990 acetylcholinesterase activity
- GO:0001540 amyloid-beta binding
- GO:0004104 cholinesterase activity
- GO:0005518 collagen binding
- GO:0016787 hydrolase activity
- GO:0043236 laminin binding
- GO:0042803 protein homodimerization activity
- GO:0017171 serine hydrolase activity
- GO:0006581 acetylcholine catabolic process
- GO:0001507 acetylcholine catabolic process in synaptic cleft
- GO:0042982 amyloid precursor protein metabolic process
- GO:0007155 cell adhesion
- GO:0032223 negative regulation of synaptic transmission, cholinergic
- GO:0007399 nervous system development
- GO:0002076 osteoblast development
- GO:0120162 positive regulation of cold-induced thermogenesis
- GO:0050714 positive regulation of protein secretion
- GO:0007416 synapse assembly
Disease associations
- OMIM:100740 RAW:OMIM_100740
- obsolete yt blood group antigen MONDO:0020626
Drugs targeting this protein · 24
- ISOFLUROPHATE inhibitor
- EDROPHONIUM CHLORIDE inhibitor
- DISTIGMINE inhibitor
- ECHOTHIOPHATE IODIDE inhibitor
- DEMECARIUM BROMIDE inhibitor
- AMBENONIUM CHLORIDE inhibitor
- HEXAFLUORENIUM BROMIDE inhibitor
- RIVASTIGMINE TARTRATE inhibitor
- ECHOTHIOPHATE inhibitor
- MINAPRINE HYDROCHLORIDE inhibitor
- GALANTAMINE HYDROBROMIDE inhibitor
- TACRINE HYDROCHLORIDE inhibitor
- DONEPEZIL HYDROCHLORIDE inhibitor
- PROPANIDID inhibitor
- ACOTIAMIDE HYDROCHLORIDE inhibitor
- ITOPRIDE inhibitor
- NEOSTIGMINE METHYLSULFATE inhibitor
- MINAPRINE inhibitor
- PHYSOSTIGMINE SALICYLATE inhibitor
- HUPERZINE A inhibitor
- BENZGALANTAMINE GLUCONATE inhibitor
- RIVASTIGMINE inhibitor
- PRALIDOXIME CHLORIDE activator
- PYRIDOSTIGMINE BROMIDE inhibitor
Related proteins · sequence + function similarity
- Acetylcholinesterase 0.99
- Acetylcholinesterase 0.99
- Acetylcholinesterase 0.98
- Acetylcholinesterase 0.98
- Acetylcholinesterase 0.98
- Acetylcholinesterase 0.87
- Carboxylesterase 3 0.86
- Carboxylesterase 3 0.85
- Cocaine esterase 0.85
- Carboxylesterase 5A 0.84
- Cocaine esterase 0.84
- Carboxylesterase 3A 0.80
Co-cited proteins · studied together in the literature
- Fasciculin-2 4 shared papers
- Acetylcholinesterase collagenic tail peptide 1 shared papers
- Cholinesterase 1 shared papers
- Erythropoietin 1 shared papers
- Ribonuclease P protein subunit p20 1 shared papers
- Transferrin receptor protein 2 1 shared papers
- Solute carrier family 12 member 9 1 shared papers
- Ufm1-specific protease 1 1 shared papers
- GRB10-interacting GYF protein 1 1 shared papers
- Solute carrier family 12 member 9 1 shared papers
- Thyroid receptor-interacting protein 6 1 shared papers
- Ufm1-specific protease 1 1 shared papers
Literature · 17 cited papers
- Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase. Biochem. J. · 2013
- Structures of human acetylcholinesterase in complex with pharmacologically important ligands. J. Med. Chem. · 2012
- Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation. J. Med. Chem. · 2010
- The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix. EMBO J. · 2004
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- The DNA sequence of human chromosome 7. Nature · 2003
- Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. Neurosci. Res. · 2002
- Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res. · 2001
- Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II. Acta Crystallogr. D · 2000
- External and internal electrostatic potentials of cholinesterase models. J. Mol. Graph. Model. · 1997
- Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism. Am. J. Hum. Genet. · 1993
- … and 5 more in the literature graph
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.