C-C chemokine receptor type 1
Also known as: CCR1, CMKBR1, CMKR1, SCYAR1
Function
Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4 (By similarity). Also mediates monocyte migration upon CXCL4 binding. Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (By similarity).
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- CCR1-9-like, Chemokine_CCR1, Chemokine_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 3
A predicted model is available from AlphaFold.
Gene Ontology · 36
- GO:0005737 cytoplasm
- GO:0009897 external side of plasma membrane
- GO:0005886 plasma membrane
- GO:0019957 C-C chemokine binding
- GO:0016493 C-C chemokine receptor activity
- GO:0071791 chemokine (C-C motif) ligand 5 binding
- GO:0035717 chemokine (C-C motif) ligand 7 binding
- GO:0004950 chemokine receptor activity
- GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity
- GO:0006816 calcium ion transport
- GO:0019722 calcium-mediated signaling
- GO:0007155 cell adhesion
- GO:0060326 cell chemotaxis
- GO:0007166 cell surface receptor signaling pathway
- GO:0007267 cell-cell signaling
- GO:0070098 chemokine-mediated signaling pathway
- GO:0006935 chemotaxis
- GO:0019221 cytokine-mediated signaling pathway
- GO:0002407 dendritic cell chemotaxis
- GO:0006887 exocytosis
- GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- GO:0006955 immune response
- GO:0006954 inflammatory response
- GO:0006874 intracellular calcium ion homeostasis
- GO:0002548 monocyte chemotaxis
- GO:0030502 negative regulation of bone mineralization
- GO:0010629 negative regulation of gene expression
- GO:0051928 positive regulation of calcium ion transport
- GO:0030335 positive regulation of cell migration
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0070374 positive regulation of ERK1 and ERK2 cascade
- GO:0050729 positive regulation of inflammatory response
- GO:0090026 positive regulation of monocyte chemotaxis
- GO:0150078 positive regulation of neuroinflammatory response
- GO:0045672 positive regulation of osteoclast differentiation
- GO:0009611 response to wounding
Drugs targeting this protein · 3
- AZD4818 antagonist
- BMS-817399 antagonist
- CCX354 antagonist
Related proteins · sequence + function similarity
- C-C chemokine receptor type 1 0.99
- C-C chemokine receptor type 1 0.99
- C-C chemokine receptor type 1 0.99
- C-C chemokine receptor type 3 0.98
- C-C chemokine receptor type 3 0.98
- C-C chemokine receptor type 3 0.98
- Probable C-C chemokine receptor type 3 0.98
- C-C chemokine receptor type 3 0.98
- C-C chemokine receptor type 3 0.98
- C-C chemokine receptor type 3 0.98
- C-C chemokine receptor type 3 0.98
- C-C chemokine receptor type 5 0.97
Co-cited proteins · studied together in the literature
- G protein-coupled receptor homolog US28 1 shared papers
- C-C motif chemokine 7 1 shared papers
- Cyclic AMP-responsive element-binding protein 3 2 shared papers
- Platelet factor 4 1 shared papers
- C-C chemokine receptor type 2 2 shared papers
- Hydroxycarboxylic acid receptor 3 1 shared papers
- C-C motif chemokine 6 1 shared papers
- C-C motif chemokine 9 1 shared papers
- Viral macrophage inflammatory protein 2 1 shared papers
- N-formyl peptide receptor 2 1 shared papers
- C-C chemokine receptor type 5 1 shared papers
- C-C motif chemokine 23 1 shared papers
Literature · 12 cited papers
- Low shear stress induces macrophage infiltration and aggravates aneurysm wall inflammation via CCL7/CCR1/TAK1/NF-kappaB axis. Cell. Signal. · 2024
- Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nat. Chem. Biol. · 2022
- CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration. Sci. Rep. · 2018
- Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration. Exp. Mol. Med. · 2008
- Proteolytic activation of alternative CCR1 ligands in inflammation. J. Immunol. · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines. FASEB J. · 2004
- Differential chemokine activation of CC chemokine receptor 1-regulated pathways: ligand selective activation of Galpha 14-coupled pathways. Eur. J. Immunol. · 2004
- A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science · 1997
- Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. J. Exp. Med. · 1993
- Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell · 1993
- Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. Int. Immunol. · 1993
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