Syndecan-4

Function

Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.

Classification

Family (Pfam)

PF01034 Syndecan

InterPro

Neurexin-like, Syndecan, Syndecan/Neurexin_dom, Syndecan_CS

Functional cluster

Secreted Growth Factors & Cytokines

Experimental structures · PDB · 5

• 1EJP NMR
• 1EJQ NMR
• 1OBY X-ray 1.85A
• 1YBO X-ray 2.30A
• 8BLV X-ray 1.50A

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0009986 cell surface
• GO:0043034 costamere
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0005796 Golgi lumen
• GO:0043202 lysosomal lumen
• GO:0005886 plasma membrane
• GO:0001968 fibronectin binding
• GO:0042802 identical protein binding
• GO:0005080 protein kinase C binding
• GO:0070053 thrombospondin receptor activity
• GO:0016477 cell migration
• GO:0042130 negative regulation of T cell proliferation
• GO:1903543 positive regulation of exosomal secretion
• GO:1903553 positive regulation of extracellular exosome assembly
• GO:0051894 positive regulation of focal adhesion assembly
• GO:0051496 positive regulation of stress fiber assembly
• GO:0010762 regulation of fibroblast migration
• GO:0001657 ureteric bud development

Drugs targeting this protein · 1

• REPOTRECTINIB inhibitor

Related proteins · sequence + function similarity

• Syndecan-4 0.99
• Syndecan-4 0.96
• Syndecan-4 0.96
• Syndecan-4 0.95
• Syndecan-4 0.90
• Syndecan-2 0.87
• Syndecan-2 0.87
• Syndecan-2 0.86
• Syndecan-2 0.86
• Syndecan-2-B 0.84
• Syndecan-2-A 0.84
• Syndecan-1 0.72

Co-cited proteins · studied together in the literature

• Syndecan-1 5 shared papers
• Apoptosis inhibitor 5 1 shared papers
• Syntenin-1 3 shared papers
• Interleukin-5 receptor subunit alpha 1 shared papers
• CUB domain-containing protein 1 1 shared papers
• Cadherin-3 1 shared papers
• Cadherin-2 1 shared papers
• Suppressor of tumorigenicity 14 protein 1 shared papers
• Sushi repeat-containing protein SRPX 2 shared papers
• Syndecan-2 1 shared papers
• Collagen alpha-1(XV) chain 2 shared papers
• Collagen alpha-1(XII) chain 1 shared papers

Literature · 18 cited papers

• Mass spectrometric analysis of chondroitin sulfate-linked peptides. J. Proteins Proteom. · 2022
• An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer. Glycobiology · 2020
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Nat. Cell Biol. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• The binding of the PDZ tandem of syntenin to target proteins. Biochemistry · 2006
• Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Widespread production of novel soluble protein isoforms by alternative splicing removal of transmembrane anchoring domains. FEBS Lett. · 2003
• Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm. Structure · 2003
• The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001
• … and 6 more in the literature graph