Repotrectinib
SMILES C[C@H]1CNC(=O)c2cnn3ccc(nc23)N[C@H](C)c2cc(F)ccc2O1
Structure
2D skeletal formula · rendered by chemkit from PubChem 2D coordinates.
Pseudo-3D ball-and-stick · chemkit, from PubChem 3D conformer coordinates.
Protein targets · 8 targets
- High affinity nerve growth factor receptor P04629 · inhibitor · Nerve growth factor receptor Trk-A inhibitor
- BDNF/NT-3 growth factors receptor Q16620 · inhibitor · Neurotrophic tyrosine kinase receptor type 2 inhibitor
- Proto-oncogene tyrosine-protein kinase ROS P08922 · inhibitor · Proto-oncogene tyrosine-protein kinase ROS inhibitor
- NT-3 growth factor receptor Q16288 · inhibitor · NT-3 growth factor receptor inhibitor
- HLA class II histocompatibility antigen gamma chain P04233 · inhibitor · CD74-ROS1 inhibitor
- Proto-oncogene tyrosine-protein kinase ROS P08922 · inhibitor · CD74-ROS1 inhibitor
- Proto-oncogene tyrosine-protein kinase ROS P08922 · inhibitor · ROS1-SDC4 inhibitor
- Syndecan-4 P31431 · inhibitor · ROS1-SDC4 inhibitor
Each resolved target links to its lmmol protein document; action and mechanism are from the bioactivity record.
A document in the lmmol reference corpus — a real compound (PubChem / ChEMBL identity, chemkit-rendered structure) cross-linked to the protein documents it targets. Hover any link to preview its target.