Ribonucleoside-diphosphate reductase subunit M2

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.

Classification

Family (Pfam)

PF00268 Ribonuc_red_sm

InterPro

Ferritin-like_SF, RNR-like, RNR_small, RNR_small_AS, RNR_small_fam

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 5

• 2UW2 X-ray 2.80A
• 3OLJ X-ray 2.10A
• 3VPM X-ray 2.70A
• 3VPN X-ray 2.25A
• 3VPO X-ray 2.30A

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0005829 cytosol
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0005971 ribonucleoside-diphosphate reductase complex
• GO:0008199 ferric iron binding
• GO:0042803 protein homodimerization activity
• GO:0036175 ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor
• GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
• GO:0009265 2'-deoxyribonucleotide biosynthetic process
• GO:0009263 deoxyribonucleotide biosynthetic process
• GO:0006281 DNA repair
• GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
• GO:0051290 protein heterotetramerization
• GO:0009185 ribonucleoside diphosphate metabolic process

Drugs targeting this protein · 5

• FLUDARABINE PHOSPHATE inhibitor
• GEMCITABINE HYDROCHLORIDE inhibitor
• CLOFARABINE inhibitor
• TEZACITABINE inhibitor
• HYDROXYUREA inhibitor

Related proteins · sequence + function similarity

• Ribonucleoside-diphosphate reductase subunit M2 1.00
• Ribonucleoside-diphosphate reductase subunit M2 0.98
• Ribonucleoside-diphosphate reductase subunit M2 0.98
• Ribonucleoside-diphosphate reductase subunit M2 0.97
• Ribonucleoside-diphosphate reductase subunit M2 0.95
• Ribonucleoside-diphosphate reductase subunit M2 B 0.92
• Ribonucleoside-diphosphate reductase subunit M2 B 0.92
• Ribonucleoside-diphosphate reductase subunit M2 B 0.92
• Ribonucleoside-diphosphate reductase subunit M2 B 0.92
• Ribonucleoside-diphosphate reductase subunit M2 0.89
• Ribonucleoside-diphosphate reductase small chain 0.88
• Ribonucleoside-diphosphate reductase small chain 0.86

Co-cited proteins · studied together in the literature

• Ribonucleoside-diphosphate reductase large subunit 1 shared papers
• Cyclin-F 1 shared papers

Literature · 10 cited papers

• Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair. Cell · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Characterization of the human ribonucleotide reductase M2 subunit gene; genomic structure and promoter analyses. Cytogenet. Cell Genet. · 2001
• Sequence analysis of the large and small subunits of human ribonucleotide reductase. DNA Seq. · 1992