B2 bradykinin receptor
Also known as: BDKRB2, BKR2
Function
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- Brdyknn_2_rcpt, Brdyknn_rcpt, CCR1-9-like, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 3
A predicted model is available from AlphaFold.
Gene Ontology · 19
- GO:0005768 endosome
- GO:0005886 plasma membrane
- GO:0004947 bradykinin receptor activity
- GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity
- GO:0002020 protease binding
- GO:0046982 protein heterodimerization activity
- GO:0031702 type 1 angiotensin receptor binding
- GO:0050482 arachidonate secretion
- GO:0008015 blood circulation
- GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
- GO:0007166 cell surface receptor signaling pathway
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006954 inflammatory response
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0043114 regulation of vascular permeability
- GO:0019229 regulation of vasoconstriction
- GO:0006939 smooth muscle contraction
- GO:0042310 vasoconstriction
- GO:0042311 vasodilation
Drugs targeting this protein · 4
- ICATIBANT ACETATE antagonist
- LABRADIMIL agonist
- ANATIBANT antagonist
- FASITIBANT CHLORIDE antagonist
Related proteins · sequence + function similarity
- B2 bradykinin receptor 0.99
- B2 bradykinin receptor 0.99
- B2 bradykinin receptor 0.98
- B2 bradykinin receptor 0.98
- B2 bradykinin receptor 0.98
- Apelin receptor A 0.90
- Type-2 angiotensin II receptor 0.90
- Apelin receptor B 0.90
- Apelin receptor 0.90
- Type-2 angiotensin II receptor 0.90
- B1 bradykinin receptor 0.90
- B1 bradykinin receptor 0.89
Co-cited proteins · studied together in the literature
- B2 bradykinin receptor 2 shared papers
- B2 bradykinin receptor 2 shared papers
- Platelet endothelial cell adhesion molecule 1 shared papers
- Guanine nucleotide-binding protein G(q) subunit alpha 1 shared papers
Literature · 10 cited papers
- Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1. Biochemistry · 2008
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function. J. Biol. Chem. · 2001
- Structure of the bradykinin B2 receptors' amino terminus. Biochemistry · 1996
- Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity. Mol. Pharmacol. · 1993
- Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. Genomics · 1993
- Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. Genomics · 1994
- Identification of polymorphic sites of the human bradykinin B2 receptor gene. Biochem. Biophys. Res. Commun. · 1995
- Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene. Biochem. Biophys. Res. Commun. · 1992
- Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. Biochem. Biophys. Res. Commun. · 1992
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