Type-2 angiotensin II receptor

Function

Receptor for angiotensin II, a vasoconstricting peptide. Primarily signals via a non-canonical G protein- and beta-arrestin independent pathways. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

ATII_AT2_rcpt, ATII_rcpt, CCR1-9-like, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM

Functional cluster

G Protein-Coupled Receptors

Experimental structures · PDB · 7

• 5UNF X-ray 2.80A
• 5UNG X-ray 2.80A
• 5UNH X-ray 2.90A
• 5XJM X-ray 3.20A
• 6JOD X-ray 3.20A
• 7C6A X-ray 3.40A
• 7JNI X-ray 3.00A

A predicted model is available from AlphaFold.

Gene Ontology · 24

• GO:0005886 plasma membrane
• GO:0004945 angiotensin type II receptor activity
• GO:0048019 receptor antagonist activity
• GO:0002033 angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
• GO:0001974 blood vessel remodeling
• GO:0007420 brain development
• GO:0007166 cell surface receptor signaling pathway
• GO:0035640 exploration behavior
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007199 G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
• GO:0006954 inflammatory response
• GO:0043537 negative regulation of blood vessel endothelial cell migration
• GO:0030308 negative regulation of cell growth
• GO:0010459 negative regulation of heart rate
• GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
• GO:0038060 nitric oxide-cGMP-mediated signaling
• GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
• GO:0045893 positive regulation of DNA-templated transcription
• GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
• GO:0072300 positive regulation of metanephric glomerulus development
• GO:0008217 regulation of blood pressure
• GO:0035566 regulation of metanephros size
• GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin
• GO:0042311 vasodilation

Drugs targeting this protein · 1

• OLODANRIGAN antagonist

Related proteins · sequence + function similarity

• Type-2 angiotensin II receptor 1.00
• Type-2 angiotensin II receptor 1.00
• Type-2 angiotensin II receptor 1.00
• Type-2 angiotensin II receptor 1.00
• Type-1 angiotensin II receptor 0.96
• Type-1 angiotensin II receptor A 0.95
• Type-1 angiotensin II receptor B 0.95
• Type-1 angiotensin II receptor B 0.95
• Type-1 angiotensin II receptor A 0.95
• Type-1 angiotensin II receptor A 0.95
• Type-1 angiotensin II receptor 0.95
• Type-1 angiotensin II receptor 0.95

Co-cited proteins · studied together in the literature

• Microtubule-associated tumor suppressor 1 1 shared papers
• Zinc finger protein 674 1 shared papers
• Zinc finger protein 41 1 shared papers
• Angiotensinogen 1 shared papers
• Microtubule-associated tumor suppressor 1 homolog 1 shared papers
• Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 1 shared papers

Literature · 16 cited papers

• The discovery of a new antibody for BRIL-fused GPCR structure determination. Sci. Rep. · 2020
• The crystal structure of angiotensin II type 2 receptor with endogenous peptide hormone. Structure · 2020
• Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog. Nat. Struct. Mol. Biol. · 2018
• Structural basis for selectivity and diversity in angiotensin II receptors. Nature · 2017
• XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing. Am. J. Hum. Genet. · 2013
• The DNA sequence of the human X chromosome. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. J. Biol. Chem. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• AGTR2 mutations in X-linked mental retardation. Science · 2002
• Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. Biochem. Biophys. Res. Commun. · 1994
• Molecular cloning of the human angiotensin II type 2 receptor cDNA. Biochem. Biophys. Res. Commun. · 1994
• … and 4 more in the literature graph