Alcohol dehydrogenase 6

Function

Alcohol dehydrogenase. Catalyzes the NAD-dependent oxidation of primary alcohols to the corresponding aldehydes. Oxidizes secondary alcohols to the corresponding ketones (By similarity).

Classification

Family (Pfam)

PF08240 ADH_N, PF00107 ADH_zinc_N

InterPro

ADH-like_C, ADH-like_N, ADH_Zn_CS, ER, GroES-like_sf, NAD(P)-bd_dom_sf

Functional cluster

Oxidoreductases & Polyketide Synthases

Gene Ontology · 7

• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0004022 alcohol dehydrogenase (NAD+) activity
• GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
• GO:0008270 zinc ion binding
• GO:0042573 retinoic acid metabolic process
• GO:0042572 retinol metabolic process

Drugs targeting this protein · 1

• NITREFAZOLE inhibitor

Related proteins · sequence + function similarity

• Alcohol dehydrogenase 6 0.99
• Alcohol dehydrogenase 1A 0.96
• All-trans-retinol dehydrogenase [NAD(+)] ADH4 0.96
• Alcohol dehydrogenase 1 0.95
• Alcohol dehydrogenase 1 0.95
• Alcohol dehydrogenase E chain 0.95
• Alcohol dehydrogenase 1 0.95
• Alcohol dehydrogenase 1A 0.95
• Alcohol dehydrogenase 1A 0.95
• Alcohol dehydrogenase S chain 0.95
• Alcohol dehydrogenase 1 0.95
• Alcohol dehydrogenase 1 0.95

Literature · 5 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. Proc. Natl. Acad. Sci. U.S.A. · 1991
• Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene. Biochem. Biophys. Res. Commun. · 1991