Alcohol dehydrogenase 1A

Function

Alcohol dehydrogenase. Oxidizes primary as well as secondary alcohols. Ethanol is a very poor substrate.

Classification

Family (Pfam)

PF08240 ADH_N, PF00107 ADH_zinc_N

InterPro

ADH-like_C, ADH-like_N, ADH_Zn_CS, ER, GroES-like_sf, NAD(P)-bd_dom_sf

Functional cluster

Oxidoreductases & Polyketide Synthases

Experimental structures · PDB · 2

• 1HSO X-ray 2.50A
• 1U3T X-ray 2.49A

A predicted model is available from AlphaFold.

Gene Ontology · 8

• GO:0005829 cytosol
• GO:0004022 alcohol dehydrogenase (NAD+) activity
• GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
• GO:1990362 butanol dehydrogenase (NAD+) activity
• GO:0008270 zinc ion binding
• GO:0006066 alcohol metabolic process
• GO:0042573 retinoic acid metabolic process
• GO:0042572 retinol metabolic process

Drugs targeting this protein · 2

• FOMEPIZOLE inhibitor
• NITREFAZOLE inhibitor

Related proteins · sequence + function similarity

• Alcohol dehydrogenase 1A 1.00
• Alcohol dehydrogenase 1A 0.99
• Alcohol dehydrogenase 1C 0.99
• All-trans-retinol dehydrogenase [NAD(+)] ADH1B 0.98
• Alcohol dehydrogenase 1C 0.98
• All-trans-retinol dehydrogenase [NAD(+)] ADH1B 0.98
• All-trans-retinol dehydrogenase [NAD(+)] ADH1B 0.98
• Alcohol dehydrogenase 1 0.98
• Alcohol dehydrogenase 1 0.98
• Alcohol dehydrogenase E chain 0.98
• Alcohol dehydrogenase 1 0.98
• Alcohol dehydrogenase S chain 0.98

Co-cited proteins · studied together in the literature

• Alcohol dehydrogenase 1C 3 shared papers
• All-trans-retinol dehydrogenase [NAD(+)] ADH1B 2 shared papers

Literature · 10 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors. Biochemistry · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein Sci. · 2001
• cDNA and protein structure for the alpha subunit of human liver alcohol dehydrogenase. Biochemistry · 1986
• Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence. Proc. Natl. Acad. Sci. U.S.A. · 1986
• Molecular structure of the human alcohol dehydrogenase 1 gene. FEBS Lett. · 1989
• Stereospecific oxidation of secondary alcohols by human alcohol dehydrogenases. J. Biol. Chem. · 1989
• The human class I alcohol dehydrogenase gene cluster: three genes are tandemly organized in an 80-kb-long segment of the genome. Genomics · 1990