Alcohol dehydrogenase 1C

Function

Alcohol dehydrogenase. Exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism.

Classification

Family (Pfam)

PF08240 ADH_N, PF00107 ADH_zinc_N

InterPro

ADH-like_C, ADH-like_N, ADH_Zn_CS, ER, GroES-like_sf, NAD(P)-bd_dom_sf

Functional cluster

Oxidoreductases & Polyketide Synthases

Experimental structures · PDB · 2

• 1HT0 X-ray 2.00A
• 1U3W X-ray 1.45A

A predicted model is available from AlphaFold.

Gene Ontology · 7

• GO:0005829 cytosol
• GO:0004022 alcohol dehydrogenase (NAD+) activity
• GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
• GO:0120542 ethanol dehydrogenase (NAD+) activity
• GO:0008270 zinc ion binding
• GO:0042573 retinoic acid metabolic process
• GO:0042572 retinol metabolic process

Drugs targeting this protein · 2

• FOMEPIZOLE inhibitor
• NITREFAZOLE inhibitor

Related proteins · sequence + function similarity

• Alcohol dehydrogenase 1C 1.00
• All-trans-retinol dehydrogenase [NAD(+)] ADH1B 0.99
• All-trans-retinol dehydrogenase [NAD(+)] ADH1B 0.99
• All-trans-retinol dehydrogenase [NAD(+)] ADH1B 0.99
• Alcohol dehydrogenase 1 0.99
• Alcohol dehydrogenase S chain 0.99
• Alcohol dehydrogenase 1 0.99
• Alcohol dehydrogenase 1A 0.99
• Alcohol dehydrogenase E chain 0.98
• Alcohol dehydrogenase 1A 0.98
• Alcohol dehydrogenase 1A 0.98
• Alcohol dehydrogenase 1 0.98

Co-cited proteins · studied together in the literature

• Alcohol dehydrogenase 1A 3 shared papers
• All-trans-retinol dehydrogenase [NAD(+)] ADH1B 2 shared papers

Literature · 10 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors. Biochemistry · 2004
• Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein Sci. · 2001
• Differential susceptibility of human alcohol dehydrogenase isoenzymes to anions. FEBS Lett. · 1984
• Human liver alcohol dehydrogenase. 2. The primary structure of the gamma 1 protein chain. Eur. J. Biochem. · 1984
• The gamma 1 and gamma 2 subunits of human liver alcohol dehydrogenase. cDNA structures, two amino acid replacements, and compatibility with changes in the enzymatic properties. Eur. J. Biochem. · 1986
• Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence. Proc. Natl. Acad. Sci. U.S.A. · 1986
• Molecular structure of the human alcohol dehydrogenase 3 gene. Jpn. J. Genet. · 1992