lmmol · Proteins

Dipeptidyl peptidase 4

UniProt P27487 Organism Homo sapiens Gene ADCP2, CD26, DPP4 EC 3.4.14.5

Also known as: ADCP2, CD26, DPP4

Function

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Also acts as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones such as brain natriuretic peptide 32. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.

Classification

Family (Pfam)
PF00930 DPPIV_N, PF00326 Peptidase_S9
InterPro
AB_hydrolase_fold, Pept_S9_AS, Peptidase_S9_cat, Peptidase_S9B_N, Serine_Prot_S9B/DPPIV
Functional cluster
Secreted Hydrolases & Toxins

Experimental structures · PDB · 117

A predicted model is available from AlphaFold.

Gene Ontology · 39

Drugs targeting this protein · 18

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 47 cited papers

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.