Plasminogen

UniProt P00747 Organism Homo sapiens Gene PLG EC 3.4.21.7

Also known as: PLG

Function

Protease which primary function is to degrade fibrin, the main component of blood clots. Also cleaves other components of blood clots like thrombospondin-1/THBS1 and von Willebrand factor/VWF. Can also directly and/or through the activation of other proteases degrade the various components of the extracellular matrix including collagen, fibronectin and laminin. Thereby, regulates a variety of biological processes including embryonic development, tissue remodeling, and inflammation. In ovulation, weakens the walls of the Graafian follicle (By similarity). In vitro, it is also able to cleave several complement zymogens, such as C1, C4 and C5.

Classification

Family (Pfam): PF00051 Kringle, PF00024 PAN_1, PF00089 Trypsin
InterPro: Kringle, Kringle-like, Kringle_CS, Kringle_sf, Pan_app, Pept_S1A_plasmin, Peptidase_S1_PA, Peptidase_S1_PA_chymotrypsin, Peptidase_S1A, Serine_protease_kringle, Trypsin_dom, TRYPSIN_HIS, TRYPSIN_SER
Functional cluster: Venom Serine Proteases & Phospholipase A2

Experimental structures · PDB · 49

1B2I NMR
1BML X-ray 2.90A
1BUI X-ray 2.65A
1CEA X-ray 2.06A
1CEB X-ray 2.07A
1DDJ X-ray 2.00A
1HPJ NMR
1HPK NMR
1I5K X-ray 2.70A
1KI0 X-ray 1.75A
1KRN X-ray 1.67A
1L4D X-ray 2.30A
… and 37 more

A predicted model is available from AlphaFold.

Gene Ontology · 35

Disease associations

hypoplasminogenemia MONDO:0009009
angioedema, hereditary, 4 MONDO:0025712

Drugs targeting this protein · 2

AMINOCAPROIC ACID inhibitor
TRANEXAMIC ACID inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Kazal-type trypsin inhibitor 2 shared papers
Plasminogen 2 shared papers
Complement C4 1 shared papers
Plasminogen activator 1 shared papers
Plasminogen 1 shared papers
Staphylokinase 1 shared papers
Histidine-rich glycoprotein 1 shared papers
Fibronectin-binding protein B 1 shared papers
Plasminogen 1 shared papers
Urokinase-type plasminogen activator 2 shared papers
Kininogen-1 1 shared papers
Enolase 1 shared papers

Literature · 78 cited papers

Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment <i>in vivo</i> while altering the levels of chemokines and adhesion molecules. Front. Immunol. · 2023
Crystal structure of Aedes aegypti trypsin inhibitor in complex with mu-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor. Protein Sci. · 2022
Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement. Int. J. Mol. Sci. · 2021
Screening for plasminogen mutations in hereditary angioedema patients. Genes (Basel) · 2021
Deciphering the genetics of primary angioedema with normal levels of C1 inhibitor. J. Clin. Med. · 2020
Increased Mosquito Midgut Infection by Dengue Virus Recruitment of Plasmin Is Blocked by an Endogenous Kazal-type Inhibitor. IScience · 2019
A missense mutation of the plasminogen gene in hereditary angioedema with normal C1 inhibitor in Japan. Allergy · 2018
Plasminogen gene mutation with normal C1 inhibitor hereditary angioedema: Three additional French families. Allergy · 2018
A missense mutation in the plasminogen gene, within the plasminogen kringle 3 domain, in hereditary angioedema with normal C1 inhibitor. Biochem. Biophys. Res. Commun. · 2018
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells. Elife · 2017
Hereditary angioedema with a mutation in the plasminogen gene. Allergy · 2018
Molecular Interactions of human plasminogen with fibronectin-binding Protein B (FnBPB), a fibrinogen/fibronectin-binding protein from Staphylococcus aureus. J. Biol. Chem. · 2016
… and 66 more in the literature graph

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