C-X-C chemokine receptor type 1

UniProt P25024 Organism Homo sapiens Gene CMKAR1, CXCR1, IL8RA

Also known as: CMKAR1, CXCR1, IL8RA

Function

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Classification

Family (Pfam): PF00001 7tm_1
InterPro: CCR1-9-like, Chemokine_CXCR1, Chemokine_CXCR_1/2, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
Functional cluster: G Protein-Coupled Receptors

Experimental structures · PDB · 5

1ILP NMR
1ILQ NMR
2LNL NMR
6XMN NMR
8IC0 EM 3.41A

A predicted model is available from AlphaFold.

Gene Ontology · 20

Drugs targeting this protein · 5

LADARIXIN modulator
REPARIXIN modulator
NAVARIXIN antagonist
NAVARIXIN ANHYDROUS antagonist
SX-682 inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

C-X-C chemokine receptor type 2 5 shared papers
Interleukin-8 3 shared papers
C-X-C chemokine receptor type 1 1 shared papers
C-X-C chemokine receptor type 1 1 shared papers
C-X-C chemokine receptor type 1 1 shared papers
C-X-C chemokine receptor type 3 1 shared papers
C-X-C chemokine receptor type 1 1 shared papers
C-X-C chemokine receptor type 1 1 shared papers
Guanine nucleotide-binding protein G(i) subunit alpha-2 1 shared papers

Literature · 12 cited papers

Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils. J. Mol. Evol. · 2005
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3. Genes Immun. · 2000
Structure of a CXC chemokine-receptor fragment in complex with interleukin-8. Structure · 1999
Physical association of Gi2alpha with interleukin-8 receptors. J. Biol. Chem. · 1996
The high-affinity interleukin 8 receptor gene (IL8RA) maps to the 2q33-q36 region of the human genome: cloning of a pseudogene (IL8RBP) for the low-affinity receptor. Genomics · 1993
Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2. Mol. Immunol. · 1993
Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. J. Biol. Chem. · 1994
Structure and functional expression of a human interleukin-8 receptor. Science · 1991
Characterization of two high affinity human interleukin-8 receptors. J. Biol. Chem. · 1992

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