Beta-lactamase

Function

Class C beta-lactamase which confers resistance to penicillins and cephalosporins (By similarity). Has nitrocefin-hydrolyzing activity.

Classification

Family (Pfam)

PF00144 Beta-lactamase

InterPro

AmpC, AmpC-like, AmpC_pseudomonas, Beta-lactam-related, Beta-lactam/transpept-like, Beta-lactam_class-C_AS

Functional cluster

Cell-Envelope & Peptidoglycan Enzymes

Experimental structures · PDB · 24

• 2WZX X-ray 1.40A
• 2WZZ X-ray 1.57A
• 3S1Y X-ray 1.40A
• 3S22 X-ray 1.65A
• 4GZB X-ray 1.79A
• 4HEF X-ray 1.86A
• 4NK3 X-ray 1.90A
• 4OOY X-ray 1.10A
• 4WYY X-ray 1.28A
• 4WZ4 X-ray 1.05A
• 4X68 X-ray 1.68A
• 6UQS X-ray 1.37A
• … and 12 more

A predicted model is available from AlphaFold.

Gene Ontology · 5

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0008800 beta-lactamase activity
• GO:0017001 antibiotic catabolic process
• GO:0033252 regulation of beta-lactamase activity
• GO:0046677 response to antibiotic

Drugs targeting this protein · 1

• RELEBACTAM inhibitor

Related proteins · sequence + function similarity

• Beta-lactamase CMY-1 0.92
• Beta-lactamase CMY-10 0.92
• Beta-lactamase 0.87
• Beta-lactamase 0.86
• Beta-lactamase 0.85
• Beta-lactamase 0.85
• Beta-lactamase 0.84
• Beta-lactamase 0.84
• Beta-lactamase CMY-4 0.83
• Beta-lactamase CMY-2 0.83
• Beta-lactamase 0.80
• Beta-lactamase 0.80

Co-cited proteins · studied together in the literature

• HTH-type transcriptional activator AmpR 4 shared papers
• Porin D 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase CMY-1 1 shared papers

Literature · 7 cited papers

• A Standard Numbering Scheme for Class C beta-Lactamases. Antimicrob. Agents Chemother. · 2020
• Structural and functional characterization of Pseudomonas aeruginosa global regulator AmpR. J. Bacteriol. · 2014
• Pseudomonas aeruginosa AmpR is a global transcriptional factor that regulates expression of AmpC and PoxB beta-lactamases, proteases, quorum sensing, and other virulence factors. Antimicrob. Agents Chemother. · 2005
• Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature · 2000
• Investigation of the Pseudomonas aeruginosa ampR gene and its role at the chromosomal ampC beta-lactamase promoter. FEMS Microbiol. Lett. · 1993
• Two-dimensional polyacrylamide gel electrophoresis isolation and microsequencing of Pseudomonas aeruginosa proteins. Enzyme Protein · 1993
• Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC beta-lactamase. Biochem. J. · 1990