Beta-lactamase

Function

This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

Classification

Family (Pfam)

PF00144 Beta-lactamase

InterPro

AmpC, AmpC-like, AmpC_enterobacter, Beta-lactam-related, Beta-lactam/transpept-like, Beta-lactam_class-C_AS

Functional cluster

Cell-Envelope & Peptidoglycan Enzymes

Experimental structures · PDB · 12

• 1BLS X-ray 2.30A
• 1GCE X-ray 1.80A
• 1RGZ X-ray 1.37A
• 1XX2 X-ray 1.88A
• 1Y54 X-ray 2.10A
• 2Q9M X-ray 2.05A
• 2Q9N X-ray 2.20A
• 3S4X X-ray 1.95A
• 4XUX X-ray 1.75A
• 5HAI X-ray 2.74A
• 5XHR X-ray 1.80A
• 7TI1 X-ray 2.00A

A predicted model is available from AlphaFold.

Gene Ontology · 4

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0008800 beta-lactamase activity
• GO:0017001 antibiotic catabolic process
• GO:0046677 response to antibiotic

Drugs targeting this protein · 1

• RELEBACTAM inhibitor

Related proteins · sequence + function similarity

• Beta-lactamase CMY-2 0.98
• Beta-lactamase CMY-4 0.98
• Beta-lactamase 0.98
• Beta-lactamase 0.96
• Beta-lactamase 0.95
• Beta-lactamase 0.95
• Beta-lactamase 0.92
• Beta-lactamase CMY-10 0.92
• Beta-lactamase 0.92
• Beta-lactamase CMY-1 0.92
• Beta-lactamase 0.90
• Beta-lactamase 0.90

Co-cited proteins · studied together in the literature

• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase 1 shared papers
• Beta-lactamase CMY-1 1 shared papers
• Beta-lactamase CMY-4 1 shared papers
• Beta-lactamase CMY-10 1 shared papers
• Beta-lactamase 1 shared papers

Literature · 4 cited papers

• A Standard Numbering Scheme for Class C beta-Lactamases. Antimicrob. Agents Chemother. · 2020
• Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase. Proc. Natl. Acad. Sci. U.S.A. · 1993
• Crystallographic structure of a phosphonate derivative of the Enterobacter cloacae P99 cephalosporinase: mechanistic interpretation of a beta-lactamase transition-state analog. Biochemistry · 1994
• Sequence and comparative analysis of three Enterobacter cloacae ampC beta-lactamase genes and their products. Biochem. J. · 1988