Follicle-stimulating hormone receptor

UniProt P23945 Organism Homo sapiens Gene FSHR, LGR1

Also known as: FSHR, LGR1

Function

G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.

Classification

Family (Pfam): PF00001 7tm_1, PF12369 GnHR_trans, PF13306 LRR_5, PF01462 LRRNT
InterPro: FSH_rcpt, GnHR_TM, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Gphrmn_rcpt_fam, LRR_5, LRR_dom_sf, LRRNT
Functional cluster: G Protein-Coupled Receptors

Experimental structures · PDB · 5

1XWD X-ray 2.92A
4AY9 X-ray 2.50A
4MQW X-ray 2.90A
8I2G EM 2.80A
8I2H EM 6.00A

A predicted model is available from AlphaFold.

Gene Ontology · 21

Disease associations

ovarian dysgenesis 1 MONDO:0024463
ovarian hyperstimulation syndrome MONDO:0011972

Neighborhood · nearest proteins

Nearest neighbours of Follicle-stimulating hormone receptor: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Follitropin subunit beta 2 shared papers
Lutropin-choriogonadotropic hormone receptor 2 shared papers
Thyrotropin receptor 2 shared papers
Thyrotropin receptor 1 shared papers
Glycoprotein hormones alpha chain 2 shared papers
DCC-interacting protein 13-beta 1 shared papers
DCC-interacting protein 13-alpha 1 shared papers

Literature · 33 cited papers

Functional characterization of two naturally occurring mutations (Val514Ala and Ala575Val) in follicle-stimulating hormone receptor. J. Clin. Endocrinol. Metab. · 2015
Evidence for follicle-stimulating hormone receptor as a functional trimer. J. Biol. Chem. · 2014
Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome. PLoS ONE · 2013
Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome. Hum. Mutat. · 2008
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. Mol. Cell. Endocrinol. · 2007
Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology. J. Clin. Endocrinol. Metab. · 2006
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
Structure of human follicle-stimulating hormone in complex with its receptor. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome. J. Clin. Endocrinol. Metab. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor. N. Engl. J. Med. · 2003
… and 21 more in the literature graph

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