Lutropin-choriogonadotropic hormone receptor

Function

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Classification

Family (Pfam)

PF00001 7tm_1, PF13306 LRR_5

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Gphrmn_rcpt_fam, LRR_5, LRR_dom_sf, LSH_rcpt

Functional cluster

G Protein-Coupled Receptors

Experimental structures · PDB · 4

• 7FIG EM 3.90A
• 7FIH EM 3.20A
• 7FII EM 4.30A
• 7FIJ EM 3.80A

A predicted model is available from AlphaFold.

Gene Ontology · 20

• GO:0005768 endosome
• GO:0005886 plasma membrane
• GO:0038106 choriogonadotropin hormone binding
• GO:0035472 choriogonadotropin hormone receptor activity
• GO:0008528 G protein-coupled peptide receptor activity
• GO:0004964 luteinizing hormone receptor activity
• GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
• GO:0071371 cellular response to gonadotropin stimulus
• GO:0071373 cellular response to luteinizing hormone stimulus
• GO:0050890 cognition
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• GO:0009755 hormone-mediated signaling pathway
• GO:0042700 luteinizing hormone signaling pathway
• GO:0030539 male genitalia development
• GO:0008584 male gonad development
• GO:0001541 ovarian follicle development
• GO:0022602 ovulation cycle process
• GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
• GO:0032962 positive regulation of inositol trisphosphate biosynthetic process

Disease associations

• OMIM:152790 RAW:OMIM_152790
• familial male-limited precocious puberty MONDO:0008303
• Leydig cell hypoplasia, type 1 MONDO:0009384

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Lutropin-choriogonadotropic hormone receptor 0.98
• Lutropin-choriogonadotropic hormone receptor 0.97
• Lutropin-choriogonadotropic hormone receptor 0.97
• Lutropin-choriogonadotropic hormone receptor 0.97
• Lutropin-choriogonadotropic hormone receptor 0.97
• Lutropin-choriogonadotropic hormone receptor 0.94
• Thyrotropin receptor 0.94
• Thyrotropin receptor 0.94
• Thyrotropin receptor 0.94
• Thyrotropin receptor 0.93
• Thyrotropin receptor 0.93
• Thyrotropin receptor 0.93

Co-cited proteins · studied together in the literature

• Thyrotropin receptor 3 shared papers
• Follicle-stimulating hormone receptor 2 shared papers
• Thyrotropin receptor 1 shared papers

Literature · 38 cited papers

• A splice site mutation combined with a novel missense mutation of LHCGR cause male pseudohermaphroditism. Hum. Mutat. · 2009
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
• Evidence that palmitoylation of carboxyl terminus cysteine residues of the human luteinizing hormone receptor regulates postendocytic processing. Mol. Endocrinol. · 2005
• Leydig cell hypoplasia: absent luteinizing hormone receptor cell surface expression caused by a novel homozygous mutation in the extracellular domain. J. Clin. Endocrinol. Metab. · 2004
• A novel missense homozygous inactivating mutation in the fourth transmembrane helix of the luteinizing hormone receptor in Leydig cell hypoplasia. Am. J. Med. Genet. A · 2004
• Luteinizing hormone signaling and breast cancer: polymorphisms and age of onset. J. Clin. Endocrinol. Metab. · 2003
• Mutant luteinizing hormone receptors in a compound heterozygous patient with complete Leydig cell hypoplasia: abnormal processing causes signaling deficiency. J. Clin. Endocrinol. Metab. · 2002
• Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors. EMBO J. · 2002
• Nodular Leydig cell hyperplasia in a boy with familial male-limited precocious puberty. J. Pediatr. · 2001
• Gonadotropin-independent precocious puberty due to luteinizing hormone receptor mutations in Brazilian boys: a novel constitutively activating mutation in the first transmembrane helix. J. Clin. Endocrinol. Metab. · 2000
• Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor. N. Engl. J. Med. · 1999
• … and 26 more in the literature graph