Trifunctional purine biosynthetic protein adenosine-3

Function

Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway.

Classification

Family (Pfam)

PF00586 AIRS, PF02769 AIRS_C, PF00551 Formyl_trans_N, PF01071 GARS_A, PF02843 GARS_C, PF02844 GARS_N

InterPro

ATP-grasp, ATP_grasp_subdomain_1, Formyl_transf_N, Formyl_transf_N_sf, GART, GART_AS, PreATP-grasp_dom_sf, PRibGlycinamid_synth_ATP-grasp, PRibGlycinamide_synth, PRibGlycinamide_synth_C-dom, PRibGlycinamide_synth_C_sf, PRibGlycinamide_synth_CS, PRibGlycinamide_synth_N, PurM-like_C_dom, PurM-like_C_sf, PurM-like_N, PurM-like_N_sf, PurM_cligase, Rudment_hybrid_motif

Functional cluster

DNA Glycosylases & Cofactor Biosynthesis Enzymes

Experimental structures · PDB · 40

• 1MEJ X-ray 2.00A
• 1MEN X-ray 2.23A
• 1MEO X-ray 1.72A
• 1NJS X-ray 1.98A
• 1RBM X-ray 2.30A
• 1RBQ X-ray 2.10A
• 1RBY X-ray 2.10A
• 1RBZ X-ray 2.10A
• 1RC0 X-ray 2.05A
• 1RC1 X-ray 2.25A
• 1ZLX X-ray 2.20A
• 1ZLY X-ray 2.07A
• … and 28 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0005524 ATP binding
• GO:0046872 metal ion binding
• GO:0004637 phosphoribosylamine-glycine ligase activity
• GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity
• GO:0004644 phosphoribosylglycinamide formyltransferase activity
• GO:0044208 'de novo' AMP biosynthetic process
• GO:0006189 'de novo' IMP biosynthetic process
• GO:0097294 'de novo' XMP biosynthetic process
• GO:0046084 adenine biosynthetic process
• GO:0003360 brainstem development
• GO:0021549 cerebellum development
• GO:0021987 cerebral cortex development
• GO:0006177 GMP biosynthetic process
• GO:0006164 purine nucleotide biosynthetic process
• GO:0009168 purine ribonucleoside monophosphate biosynthetic process

Drugs targeting this protein · 6

• PELITREXOL inhibitor
• PEMETREXED inhibitor
• PEMETREXED DISODIUM inhibitor
• PEMETREXED TROMETHAMINE inhibitor
• PEMETREXED MONOHYDRATE inhibitor
• PEMETREXED DIPOTASSIUM inhibitor

Related proteins · sequence + function similarity

• Trifunctional purine biosynthetic protein adenosine-3 0.97
• Trifunctional purine biosynthetic protein adenosine-3 0.97
• Trifunctional purine biosynthetic protein adenosine-3 0.97
• Trifunctional purine biosynthetic protein adenosine-3 0.79
• Trifunctional purine biosynthetic protein adenosine-3 0.75
• Bifunctional purine biosynthetic protein ADE1 0.71
• Bifunctional purine biosynthetic protein ADE5,7 0.70
• Bifunctional purine biosynthetic protein ADE5,7 0.69
• Phosphoribosylamine--glycine ligase, chloroplastic 0.68
• Bifunctional purine biosynthetic protein purD 0.65
• Phosphoribosylamine--glycine ligase 0.62
• Phosphoribosylamine--glycine ligase 0.62

Co-cited proteins · studied together in the literature

• Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase 1 shared papers
• Trifunctional purine biosynthetic protein adenosine-3 1 shared papers

Literature · 16 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Structural studies of tri-functional human GART. Nucleic Acids Res. · 2010
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase. Biochemistry · 2005
• Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat. Biotechnol. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Proteomic characterization of the human centrosome by protein correlation profiling. Nature · 2003
• Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry · 2003
• … and 4 more in the literature graph