D(1B) dopamine receptor
Also known as: DRD1B, DRD1L2, DRD5
Function
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- Dopamine_D5_rcpt, Dopamine_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 1
- 8IRV EM 3.10A
A predicted model is available from AlphaFold.
Gene Ontology · 24
- GO:0097731 9+0 non-motile cilium
- GO:0031526 brush border membrane
- GO:0060170 ciliary membrane
- GO:0005929 cilium
- GO:0097730 non-motile cilium
- GO:0005886 plasma membrane
- GO:0045202 synapse
- GO:0035240 dopamine binding
- GO:0004952 dopamine neurotransmitter receptor activity
- GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs
- GO:0004930 G protein-coupled receptor activity
- GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
- GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0071870 cellular response to catecholamine stimulus
- GO:0007268 chemical synaptic transmission
- GO:0007212 G protein-coupled dopamine receptor signaling pathway
- GO:0006874 intracellular calcium ion homeostasis
- GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
- GO:0045762 positive regulation of adenylate cyclase activity
- GO:0043410 positive regulation of MAPK cascade
- GO:0072593 reactive oxygen species metabolic process
- GO:0008217 regulation of blood pressure
- GO:0001963 synaptic transmission, dopaminergic
Disease associations
- blepharospasm, benign essential, susceptibility to MONDO:0100532
Drugs targeting this protein · 5
- AMOXAPINE antagonist
- PERGOLIDE MESYLATE agonist
- PIMOZIDE antagonist
- ERGOLOID MESYLATES agonist
- TAVAPADON partial agonist
Related proteins · sequence + function similarity
- D(1B) dopamine receptor 0.96
- D(1B) dopamine receptor 0.96
- D(5)-like dopamine receptor 0.93
- D(1A) dopamine receptor 0.92
- D(1A) dopamine receptor 0.91
- Beta-2 adrenergic receptor 0.91
- D(1)-like dopamine receptor 0.91
- D(1) dopamine receptor 0.90
- D(1)-like dopamine receptor 0.90
- D(1A) dopamine receptor 0.90
- D(1A) dopamine receptor 0.90
- D(1A) dopamine receptor 0.89
Literature · 9 cited papers
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm. Neurology · 2002
- N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells. Mol. Pharmacol. · 1999
- Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. · 1999
- The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. Hum. Mol. Genet. · 1995
- Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene. J. Biol. Chem. · 1991
- Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes. Proc. Natl. Acad. Sci. U.S.A. · 1991
- Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature · 1991
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