Atrial natriuretic peptide receptor 2

Function

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.

Classification

Family (Pfam)

PF01094 ANF_receptor, PF00211 Guanylate_cyc, PF07714 PK_Tyr_Ser-Thr

InterPro

A/G_cyclase, A/G_cyclase_CS, ANF_lig-bd_rcpt, ANPR/GUC, Cyclic_nucleotide_synthase, Kinase-like_dom_sf, Nucleotide_cyclase, Peripla_BP_I, Prot_kinase_dom, Ser-Thr/Tyr_kinase_cat_dom

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Gene Ontology · 59

• GO:0005929 cilium
• GO:0005737 cytoplasm
• GO:0043005 neuron projection
• GO:0005634 nucleus
• GO:0005886 plasma membrane
• GO:0045202 synapse
• GO:0005524 ATP binding
• GO:0005525 GTP binding
• GO:0004383 guanylate cyclase activity
• GO:0042562 hormone binding
• GO:0042802 identical protein binding
• GO:0016941 natriuretic peptide receptor activity
• GO:0017046 peptide hormone binding
• GO:0004672 protein kinase activity
• GO:0060466 activation of meiosis involved in egg activation
• GO:0060385 axonogenesis involved in innervation
• GO:0001974 blood vessel remodeling
• GO:0098868 bone growth
• GO:0061939 c-di-GMP signaling
• GO:0071321 cellular response to cGMP
• GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
• GO:1901653 cellular response to peptide
• GO:0006182 cGMP biosynthetic process
• GO:0007268 chemical synaptic transmission
• GO:0002062 chondrocyte differentiation
• GO:0035988 chondrocyte proliferation
• GO:0051276 chromosome organization
• GO:0048668 collateral sprouting
• GO:0001549 cumulus cell differentiation
• GO:0048546 digestive tract morphogenesis
• GO:0001958 endochondral ossification
• GO:0007173 epidermal growth factor receptor signaling pathway
• GO:0097194 execution phase of apoptosis
• GO:0030540 female genitalia development
• GO:0035483 gastric emptying
• GO:0035112 genitalia morphogenesis
• GO:0003417 growth plate cartilage development
• GO:0035108 limb morphogenesis
• GO:0001945 lymph vessel development
• GO:0000165 MAPK cascade
• GO:1903537 meiotic cell cycle process involved in oocyte maturation
• GO:0035264 multicellular organism growth
• GO:0051402 neuron apoptotic process
• GO:0019228 neuronal action potential
• GO:0036342 post-anal tail morphogenesis
• GO:0007168 receptor guanylyl cyclase signaling pathway
• GO:0008217 regulation of blood pressure
• GO:0071774 response to fibroblast growth factor
• GO:0034699 response to luteinizing hormone
• GO:1902074 response to salt
• GO:0007605 sensory perception of sound
• GO:0048745 smooth muscle tissue development
• GO:0007283 spermatogenesis
• GO:0001964 startle response
• GO:0007033 vacuole organization
• GO:0061042 vascular wound healing
• GO:0001570 vasculogenesis
• GO:0021647 vestibulocochlear nerve maturation
• GO:0050872 white fat cell differentiation

Disease associations

• acromesomelic dysplasia 1, Maroteaux type MONDO:0011275
• tall stature-scoliosis-macrodactyly of the great toes syndrome MONDO:0014401
• short stature with nonspecific skeletal abnormalities 1 MONDO:0014551

Drugs targeting this protein · 1

• CARPERITIDE agonist

Related proteins · sequence + function similarity

• Atrial natriuretic peptide receptor 2 1.00
• Atrial natriuretic peptide receptor 2 1.00
• Atrial natriuretic peptide receptor 2 1.00
• Atrial natriuretic peptide receptor 1 0.96
• Atrial natriuretic peptide receptor 1 0.96
• Atrial natriuretic peptide receptor 1 0.95
• Atrial natriuretic peptide receptor 2 0.83
• Retinal guanylyl cyclase 2 0.81
• Retinal guanylyl cyclase 2 0.79
• Retinal guanylyl cyclase 2 0.79
• Guanylate cyclase D 0.78
• Retinal guanylyl cyclase 2 0.78

Co-cited proteins · studied together in the literature

• Atrial natriuretic peptide receptor 1 3 shared papers
• Atrial natriuretic peptide receptor 2 1 shared papers
• Atrial natriuretic peptide receptor 1 1 shared papers
• Atrial natriuretic peptide receptor 3 1 shared papers
• Natriuretic peptides A 2 shared papers
• C-type natriuretic peptide 1 shared papers
• Natriuretic peptides B 1 shared papers

Literature · 19 cited papers

• Catalytically active guanylyl cyclase b requires endoplasmic reticulum-mediated glycosylation, and mutations that inhibit this process cause dwarfism. J. Biol. Chem. · 2016
• Identification and functional characterization of two novel NPR2 mutations in Japanese patients with short stature. J. Clin. Endocrinol. Metab. · 2014
• Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic peptide receptor 2 (NPR2) gene. Am. J. Med. Genet. A · 2014
• An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities. J. Clin. Endocrinol. Metab. · 2013
• Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature in patients initially classified as idiopathic short stature. J. Clin. Endocrinol. Metab. · 2013
• A human skeletal overgrowth mutation increases maximal velocity and blocks desensitization of guanylyl cyclase-B. Bone · 2013
• An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene. PLoS ONE · 2012
• Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B. Biochemistry · 2010
• Intact kinase homology domain of natriuretic peptide receptor-B is essential for skeletal development. J. Clin. Endocrinol. Metab. · 2007
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• DNA sequence and analysis of human chromosome 9. Nature · 2004
• … and 7 more in the literature graph