Atrial natriuretic peptide receptor 3

Function

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity).

Classification

Family (Pfam)

PF01094 ANF_receptor

InterPro

ANF_lig-bd_rcpt, ANP_Clearance_Receptor, ANPR/GUC, Peripla_BP_I

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 4

• 1JDN X-ray 2.90A
• 1JDP X-ray 2.00A
• 1YK0 X-ray 2.40A
• 1YK1 X-ray 2.90A

A predicted model is available from AlphaFold.

Gene Ontology · 22

• GO:0070062 extracellular exosome
• GO:0005886 plasma membrane
• GO:0032991 protein-containing complex
• GO:0031404 chloride ion binding
• GO:0008528 G protein-coupled peptide receptor activity
• GO:0042562 hormone binding
• GO:0016941 natriuretic peptide receptor activity
• GO:0042277 peptide binding
• GO:0017046 peptide hormone binding
• GO:0042803 protein homodimerization activity
• GO:0140319 receptor decoy activity
• GO:0001525 angiogenesis
• GO:0001974 blood vessel remodeling
• GO:0120163 negative regulation of cold-induced thermogenesis
• GO:0002158 osteoclast proliferation
• GO:1901082 positive regulation of relaxation of smooth muscle
• GO:0035810 positive regulation of urine volume
• GO:0008217 regulation of blood pressure
• GO:0033688 regulation of osteoblast proliferation
• GO:0002931 response to ischemia
• GO:0007165 signal transduction
• GO:0001501 skeletal system development

Disease associations

• Boudin-Mortier syndrome MONDO:0859194

Drugs targeting this protein · 1

• CARPERITIDE agonist

Related proteins · sequence + function similarity

• Atrial natriuretic peptide receptor 3 0.99
• Atrial natriuretic peptide receptor 3 0.98
• Atrial natriuretic peptide receptor 3 0.98
• Atrial natriuretic peptide receptor 2 0.68
• Atrial natriuretic peptide receptor 2 0.68
• Atrial natriuretic peptide receptor 2 0.67
• Atrial natriuretic peptide receptor 2 0.67
• Atrial natriuretic peptide receptor 1 0.66
• Atrial natriuretic peptide receptor 1 0.66
• Receptor-type guanylate cyclase gcy-28 0.66
• Retinal guanylyl cyclase 2 0.64
• Atrial natriuretic peptide receptor 1 0.63

Co-cited proteins · studied together in the literature

• C-type natriuretic peptide 1 shared papers
• Natriuretic peptides A 2 shared papers
• Atrial natriuretic peptide receptor 1 1 shared papers
• Atrial natriuretic peptide receptor 2 1 shared papers
• Natriuretic peptides B 1 shared papers

Literature · 10 cited papers

• Bi-allelic Loss-of-Function Mutations in the NPR-C Receptor Result in Enhanced Growth and Connective Tissue Abnormalities. Am. J. Hum. Genet. · 2018
• Structural determinants of natriuretic peptide receptor specificity and degeneracy. J. Mol. Biol. · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and comparative analysis of human chromosome 5. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. Science · 2001
• The disulfide linkages and glycosylation sites of the human natriuretic peptide receptor-C homodimer. Biochemistry · 1994
• Isolation and functional expression of the human atrial natriuretic peptide clearance receptor cDNA. Biochem. Biophys. Res. Commun. · 1990
• cDNA sequence of the human atrial natriuretic peptide clearance receptor. Nucleic Acids Res. · 1990
• Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera. J. Biol. Chem. · 1991