Integrin beta-5

Function

Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.

Classification

Family (Pfam)

PF23105 EGF_integrin, PF18372 I-EGF_1, PF08725 Integrin_b_cyt, PF07965 Integrin_B_tail, PF00362 Integrin_beta, PF17205 PSI_integrin

InterPro

EGF_integrin_1, EGF_integrin_2, Integrin_beta_N, Integrin_bsu, Integrin_bsu_cyt_dom, Integrin_bsu_tail, Integrin_bsu_tail_dom_sf, Integrin_bsu_VWA, Integrin_dom_sf, PSI, VWF_A, vWFA_dom_sf

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 3

• 7S46 X-ray 2.10A
• 7S47 X-ray 2.00A
• 7S48 X-ray 1.90A

A predicted model is available from AlphaFold.

Gene Ontology · 21

• GO:0009986 cell surface
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0034684 integrin alphav-beta5 complex
• GO:0008305 integrin complex
• GO:0045335 phagocytic vesicle
• GO:0005886 plasma membrane
• GO:0043235 receptor complex
• GO:0005178 integrin binding
• GO:0046872 metal ion binding
• GO:0001618 virus receptor activity
• GO:0033627 cell adhesion mediated by integrin
• GO:0016477 cell migration
• GO:0098609 cell-cell adhesion
• GO:0007160 cell-matrix adhesion
• GO:0035987 endodermal cell differentiation
• GO:0090136 epithelial cell-cell adhesion
• GO:0007229 integrin-mediated signaling pathway
• GO:0043149 stress fiber assembly
• GO:0007179 transforming growth factor beta receptor signaling pathway
• GO:0035313 wound healing, spreading of epidermal cells

Drugs targeting this protein · 1

• CILENGITIDE antagonist

Related proteins · sequence + function similarity

• Integrin beta-5 0.99
• Integrin beta-5 0.99
• Integrin beta-3 0.96
• Integrin beta-5 0.95
• Integrin beta-3 0.94
• Integrin beta-3 0.93
• Integrin beta-6 0.91
• Integrin beta-6 0.91
• Integrin beta-6 0.90
• Integrin beta-6 0.90
• Integrin beta-6 0.90
• Integrin beta-6 0.89

Co-cited proteins · studied together in the literature

• CCN family member 3 1 shared papers
• CCN family member 3 1 shared papers
• Unconventional myosin-X 1 shared papers
• Penton protein 1 shared papers
• Penton protein 1 shared papers
• Ras GTPase-activating protein nGAP 1 shared papers
• Tensin-3 1 shared papers
• Inactive tyrosine-protein kinase PEAK1 1 shared papers
• Integrin beta-3 2 shared papers
• Integrin beta-1 2 shared papers
• Integrin alpha-V 1 shared papers
• Inactive tyrosine-protein kinase PEAK1 1 shared papers

Literature · 11 cited papers

• PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins. J. Cell Biol. · 2022
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. Virol. J. · 2010
• Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing. J. Biol. Chem. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Myosin-X provides a motor-based link between integrins and the cytoskeleton. Nat. Cell Biol. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit. Proc. Natl. Acad. Sci. U.S.A. · 1990
• Cloning, primary structure and properties of a novel human integrin beta subunit. EMBO J. · 1990
• cDNA sequence of the human integrin beta 5 subunit. J. Biol. Chem. · 1990