Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
Also known as: PDE6A, PDEA
Function
Catalytic alpha subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification. Decreased cytosolic cGMP levels result in closure of cGMP-gated cation channels at the plasma membrane, leading to rod photoreceptor hyperpolarization (By similarity).
Classification
- Family (Pfam)
- PF01590 GAF, PF00233 PDEase_I
- InterPro
- GAF, GAF-like_dom_sf, HD/PDEase_dom, PDEase, PDEase_catalytic_dom, PDEase_catalytic_dom_sf, PDEase_CS
- Functional cluster
- Oxidoreductases, Catalases & Peroxidases
Gene Ontology · 10
- GO:0097381 photoreceptor disc membrane
- GO:0042622 photoreceptor outer segment membrane
- GO:0005886 plasma membrane
- GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
- GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
- GO:0046872 metal ion binding
- GO:0141162 negative regulation of cAMP/PKA signal transduction
- GO:0060041 retina development in camera-type eye
- GO:0007165 signal transduction
- GO:0007601 visual perception
Disease associations
- retinitis pigmentosa 43 MONDO:0013437
Drugs targeting this protein · 2
- PENTOXIFYLLINE inhibitor
- DIPYRIDAMOLE inhibitor
Related proteins · sequence + function similarity
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 1.00
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 1.00
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 0.99
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 0.99
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 0.98
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta 0.97
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta 0.97
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 0.97
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 0.97
- Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' 0.96
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta 0.96
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta 0.95
Co-cited proteins · studied together in the literature
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta 1 shared papers
- Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha 1 shared papers
Literature · 5 cited papers
- Rod phosphodiesterase-6 PDE6A and PDE6B subunits are enzymatically equivalent. J. Biol. Chem. · 2010
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Frequency of mutations in the gene encoding the alpha subunit of rod cGMP-phosphodiesterase in autosomal recessive retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. · 1999
- Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase. Nat. Genet. · 1995
- Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene. Genomics · 1990
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