Thymidylate synthase

Classification

Family (Pfam)

PF00303 Thymidylat_synt

InterPro

Thymidate_synth/dCMP_Mease, Thymidate_synth/dCMP_Mease_dom, Thymidate_synth/dCMP_Mease_sf, Thymidylate_synthase, Thymidylate_synthase_AS

Functional cluster

M20 Family Metallopeptidases

Gene Ontology · 6

• GO:0005829 cytosol
• GO:0005739 mitochondrion
• GO:0004799 thymidylate synthase activity
• GO:0006231 dTMP biosynthetic process
• GO:0006235 dTTP biosynthetic process
• GO:0032259 methylation

Drugs targeting this protein · 1

• FLUCYTOSINE inhibitor

Related proteins · sequence + function similarity

• Thymidylate synthase 0.93
• Thymidylate synthase 0.93
• Thymidylate synthase 0.92
• Thymidylate synthase 0.90
• Thymidylate synthase 1/2 0.90
• Thymidylate synthase 3 0.90
• Thymidylate synthase 0.89
• Thymidylate synthase 0.89
• Thymidylate synthase 0.89
• Thymidylate synthase 0.89
• Thymidylate synthase 0.88
• Thymidylate synthase 0.88

Literature · 2 cited papers

• The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science · 2005
• Cloning, expression and characterization of thymidylate synthase from Cryptococcus neoformans. Gene · 1994