Large ribosomal subunit protein bL31

UniProt P0A7M9 Organism Escherichia coli (strain K12) Gene JW3907, b3936, rpmE

Also known as: JW3907, b3936, rpmE

Function

Binds the 23S rRNA.

Classification

Family (Pfam): PF01197 Ribosomal_L31
InterPro: Ribosomal_bL28/bL31-like_sf, Ribosomal_bL31, Ribosomal_bL31_A, Ribosomal_bL31_sf
Functional cluster: Small-Subunit Ribosomal Proteins

Experimental structures · PDB · 319

2J28 EM 8.00A
2RDO EM 9.10A
3BBX EM 10.00A
3J9Y EM 3.90A
3J9Z EM 3.60A
3JA1 EM 3.60A
4V4H X-ray 3.46A
4V4Q X-ray 3.46A
4V5B X-ray 3.74A
4V65 EM 9.00A
4V66 EM 9.00A
4V6K EM 8.25A
… and 307 more

A predicted model is available from AlphaFold.

Gene Ontology · 10

Drugs targeting this protein · 62

TELITHROMYCIN inhibitor
DEMECLOCYCLINE HYDROCHLORIDE inhibitor
ERYTHROMYCIN LACTOBIONATE inhibitor
ERYTHROMYCIN STEARATE inhibitor
CLINDAMYCIN HYDROCHLORIDE inhibitor
CLINDAMYCIN PALMITATE HYDROCHLORIDE inhibitor
QUINUPRISTIN inhibitor
ERYTHROMYCIN ETHYLSUCCINATE inhibitor
DOXYCYCLINE inhibitor
CHLORAMPHENICOL SODIUM SUCCINATE inhibitor
MINOCYCLINE HYDROCHLORIDE inhibitor
DALFOPRISTIN inhibitor
TETRACYCLINE PHOSPHATE COMPLEX inhibitor
DIRITHROMYCIN inhibitor
TEDIZOLID inhibitor
LINEZOLID inhibitor
CHLORAMPHENICOL inhibitor
TETRACYCLINE inhibitor
KANAMYCIN SULFATE inhibitor
LINCOMYCIN inhibitor
OXYTETRACYCLINE inhibitor
OXYTETRACYCLINE HYDROCHLORIDE inhibitor
DELPAZOLID inhibitor
CLARITHROMYCIN inhibitor
BEKANAMYCIN inhibitor
ERAVACYCLINE inhibitor
OMADACYCLINE TOSYLATE inhibitor
TYLVALOSIN TARTRATE inhibitor
TEDIZOLID PHOSPHATE inhibitor
GAMITHROMYCIN inhibitor
CHLORTETRACYCLINE HYDROCHLORIDE inhibitor
METHACYCLINE HYDROCHLORIDE inhibitor
PAROMOMYCIN SULFATE inhibitor
SISOMICIN inhibitor
ERYTHROMYCIN ESTOLATE inhibitor
ERAVACYCLINE DIHYDROCHLORIDE inhibitor
JOSAMYCIN inhibitor
PLAZOMICIN SULFATE inhibitor
MECLOCYCLINE SULFOSALICYLATE inhibitor
TILDIPIROSIN inhibitor
QUINUPRISTIN/DALFOPRISTIN inhibitor
CLINDAMYCIN PHOSPHATE inhibitor
STREPTOMYCIN SULFATE inhibitor
DIHYDROSTREPTOMYCIN SULFATE inhibitor
CONTEZOLID inhibitor
ERYTHROMYCIN GLUCEPTATE inhibitor
LEFAMULIN ACETATE inhibitor
CADAZOLID inhibitor
TIGECYCLINE inhibitor
OXYTETRACYCLINE CALCIUM inhibitor
SPECTINOMYCIN HYDROCHLORIDE inhibitor
DOXYCYCLINE HYCLATE inhibitor
NETILMICIN SULFATE inhibitor
PIRLIMYCIN HYDROCHLORIDE inhibitor
CETHROMYCIN inhibitor
CONTEZOLID ACEFOSAMIL inhibitor
AMIKACIN SULFATE inhibitor
NAFITHROMYCIN inhibitor
TETRACYCLINE HYDROCHLORIDE inhibitor
RADEZOLID inhibitor
AZITHROMYCIN inhibitor
ERYTHROMYCIN inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

High-affinity zinc uptake system protein ZnuA 1 shared papers
Metal-binding protein ZinT 1 shared papers
Large ribosomal subunit protein bL31B 1 shared papers
Inhibitor of vertebrate lysozyme 1 shared papers
Protein YihD 1 shared papers
Uncharacterized protein YnfD 1 shared papers
Uncharacterized protein YjbR 1 shared papers
Uncharacterized protein YccU 1 shared papers
UPF0337 protein YjbJ 1 shared papers
Protein YciN 1 shared papers
Uncharacterized protein YccJ 1 shared papers
Probable Fe(2+)-trafficking protein 1 shared papers

Literature · 15 cited papers

Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome. Nature · 2017
Translational termination without a stop codon. Science · 2016
Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature · 2017
Mechanistic insights into the alternative translation termination by ArfA and RF2. Nature · 2017
A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
Characterization of Zn(II)-responsive ribosomal proteins YkgM and L31 in E. coli. J. Inorg. Biochem. · 2012
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol. Cell. Proteomics · 2009
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
Structures of the bacterial ribosome at 3.5 A resolution. Science · 2005
Characterization of Escherichia coli 50S ribosomal protein L31. FEMS Microbiol. Lett. · 1999
Observation of Escherichia coli ribosomal proteins and their posttranslational modifications by mass spectrometry. Anal. Biochem. · 1999
Small genes/gene-products in Escherichia coli K-12. FEMS Microbiol. Lett. · 1998
… and 3 more in the literature graph

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