lmmol · Proteins

DNA gyrase subunit B

UniProt P0A0K8 Organism Staphylococcus aureus Gene gyrB EC 5.6.2.2

Also known as: gyrB

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Classification

Family (Pfam)
PF00204 DNA_gyraseB, PF00986 DNA_gyraseB_C, PF02518 HATPase_c, PF01751 Toprim
InterPro
DNA_gyrase_B_C, GyrB, HATPase_C_sf, HATPase_dom, Ribosomal_Su5_D2-typ_SF, Ribsml_uS5_D2-typ_fold_subgr, Topo_IIA, Topo_IIA-like_dom_sf, Topo_IIA_B, Topo_IIA_B_C, Topo_IIA_bsu_dom2, TopoIIA_CS, TOPRIM_dom, TOPRIM_GyrB
Functional cluster
S-Adenosylmethionine Synthases & related

Experimental structures · PDB · 32

A predicted model is available from AlphaFold.

Gene Ontology · 9

Drugs targeting this protein · 2

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 6 cited papers

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