Matrilysin

Function

Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Classification

Family (Pfam)

PF00413 Peptidase_M10, PF01471 PG_binding_1

InterPro

M10A_MMP, MetalloPept_cat_dom_sf, Pept_M10_metallopeptidase, Pept_M10A, Pept_M10A_Zn_BS, Peptidase_Metallo, Peptidoglycan-bd-like, PGBD-like_sf

Functional cluster

Venom Serine Proteases & Phospholipase A2

Experimental structures · PDB · 16

• 1MMP X-ray 2.30A
• 1MMQ X-ray 1.90A
• 1MMR X-ray 2.40A
• 2DDY NMR
• 2MZE NMR
• 2MZH NMR
• 2MZI NMR
• 2Y6C X-ray 1.70A
• 2Y6D X-ray 1.60A
• 5UE2 NMR
• 5UE5 NMR
• 7WXX X-ray 1.50A
• … and 4 more

A predicted model is available from AlphaFold.

Gene Ontology · 16

• GO:0070062 extracellular exosome
• GO:0031012 extracellular matrix
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0004175 endopeptidase activity
• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0008270 zinc ion binding
• GO:0030574 collagen catabolic process
• GO:0022617 extracellular matrix disassembly
• GO:0030198 extracellular matrix organization
• GO:0006509 membrane protein ectodomain proteolysis
• GO:0031293 membrane protein intracellular domain proteolysis
• GO:0030335 positive regulation of cell migration
• GO:0006508 proteolysis

Drugs targeting this protein · 4

• DOXYCYCLINE inhibitor
• DOXYCYCLINE CALCIUM inhibitor
• MARIMASTAT inhibitor
• DOXYCYCLINE HYCLATE inhibitor

Related proteins · sequence + function similarity

• Matrilysin 0.97
• Matrilysin 0.97
• Matrilysin 0.92
• Matrix metalloproteinase-20 0.81
• Matrix metalloproteinase-20 0.80
• Interstitial collagenase 0.80
• Matrix metalloproteinase-20 0.79
• Interstitial collagenase 0.79
• Stromelysin-1 0.79
• Matrix metalloproteinase-20 0.79
• Interstitial collagenase 0.79
• Matrix metalloproteinase-26 0.79

Co-cited proteins · studied together in the literature

• Stromelysin-2 1 shared papers

Literature · 7 cited papers

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J. Biol. Chem. · 1994
• Matrilysin-inhibitor complexes: common themes among metalloproteases. Biochemistry · 1995
• The collagenase gene family in humans consists of at least four members. Biochem. J. · 1988
• Pump-1 cDNA codes for a protein with characteristics similar to those of classical collagenase family members. Biochemistry · 1989
• Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line. Cancer Res. · 1990
• Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1. Biochem. J. · 1992