Interstitial collagenase

Function

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

Classification

Family (Pfam)

PF00045 Hemopexin, PF00413 Peptidase_M10, PF01471 PG_binding_1

InterPro

Hemopexin-like_dom, Hemopexin-like_dom_sf, Hemopexin-like_repeat, Hemopexin_CS, M10A_MMP, MetalloPept_cat_dom_sf, Pept_M10_metallopeptidase, Pept_M10A, Pept_M10A_Zn_BS, Peptidase_Metallo, Peptidoglycan-bd-like, PGBD-like_sf

Functional cluster

Venom Serine Proteases & Phospholipase A2

Experimental structures · PDB · 15

• 1AYK NMR
• 1CGE X-ray 1.90A
• 1CGF X-ray 2.10A
• 1CGL X-ray 2.40A
• 1HFC X-ray 1.50A
• 1SU3 X-ray 2.20A
• 2AYK NMR
• 2CLT X-ray 2.67A
• 2J0T X-ray 2.54A
• 2TCL X-ray 2.20A
• 3AYK NMR
• 3SHI X-ray 2.20A
• … and 3 more

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0031012 extracellular matrix
• GO:0005576 extracellular region
• GO:0004175 endopeptidase activity
• GO:0004222 metalloendopeptidase activity
• GO:0008233 peptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0008270 zinc ion binding
• GO:0071492 cellular response to UV-A
• GO:0030574 collagen catabolic process
• GO:0022617 extracellular matrix disassembly
• GO:0030198 extracellular matrix organization
• GO:0031334 positive regulation of protein-containing complex assembly
• GO:0006508 proteolysis

Drugs targeting this protein · 5

• DOXYCYCLINE inhibitor
• DOXYCYCLINE CALCIUM inhibitor
• MARIMASTAT inhibitor
• DOXYCYCLINE HYCLATE inhibitor
• REBIMASTAT inhibitor

Related proteins · sequence + function similarity

• Interstitial collagenase 0.99
• Interstitial collagenase 0.98
• Interstitial collagenase 0.98
• Interstitial collagenase 0.98
• Interstitial collagenase A 0.95
• Stromelysin-1 0.94
• Macrophage metalloelastase 0.94
• Stromelysin-1 0.94
• Stromelysin-1 0.94
• Matrix metalloproteinase-18 0.94
• Neutrophil collagenase 0.94
• Stromelysin-2 0.93

Co-cited proteins · studied together in the literature

• Stromelysin-1 1 shared papers
• Stromelysin-1 1 shared papers
• Protein Tat 1 shared papers
• Laminin subunit alpha-1 1 shared papers
• Extracellular tyrosine-protein kinase PKDCC 1 shared papers
• Matrix metalloproteinase-19 1 shared papers
• Extracellular tyrosine-protein kinase PKDCC 1 shared papers
• Alpha-(1,6)-fucosyltransferase 1 shared papers
• Tumor necrosis factor ligand superfamily member 10 1 shared papers
• Collagenase 3 1 shared papers
• Endoplasmic reticulum resident protein 29 1 shared papers
• Matrix metalloproteinase-14 1 shared papers

Literature · 19 cited papers

• A secreted tyrosine kinase acts in the extracellular environment. Cell · 2014
• Interaction of HIV Tat and matrix metalloproteinase in HIV neuropathogenesis: a new host defense mechanism. FASEB J. · 2006
• X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding. J. Biol. Chem. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• N-glycan structures of matrix metalloproteinase-1 derived from human fibroblasts and from HT-1080 fibrosarcoma cells. Eur. J. Biochem. · 1999
• High-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase determined by multidimensional NMR. Biochemistry · 1998
• Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor. Science · 1994
• 1.56-A structure of mature truncated human fibroblast collagenase. Proteins · 1994
• Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself. Biochemistry · 1994
• Structure of the catalytic domain of human fibroblast collagenase complexed with an inhibitor. Nat. Struct. Biol. · 1994
• 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. Mol. Cell. Biol. · 1987
• Human fibroblast collagenase contains an amino acid sequence homologous to the zinc-binding site of Serratia protease. J. Biol. Chem. · 1987
• … and 7 more in the literature graph