lmmol · Proteins

5-hydroxytryptamine receptor 1A

UniProt P08908 Organism Homo sapiens Gene ADRB2RL1, ADRBRL1, HTR1A

Also known as: ADRB2RL1, ADRBRL1, HTR1A

Function

G protein-coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Classification

Family (Pfam)
PF00001 7tm_1
InterPro
5HT1A_rcpt, 5HT_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
Functional cluster
G Protein-Coupled Receptors

Experimental structures · PDB · 28

A predicted model is available from AlphaFold.

Gene Ontology · 23

Disease associations

Drugs targeting this protein · 29

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 21 cited papers

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