D-alanyl-D-alanine carboxypeptidase DacC
Also known as: JW0823, b0839, dacC
Function
Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.
Classification
- Family (Pfam)
- PF07943 PBP5_C, PF00768 Peptidase_S11
- InterPro
- Beta-lactam/transpept-like, Peniciliin-bd_prot_C_sf, Peptidase_S11, Peptidase_S11_C, Peptidase_S11_C_sf, Peptidase_S11_N
- Functional cluster
- Membrane Insertases & Cytochromes
Experimental structures · PDB · 3
A predicted model is available from AlphaFold.
Gene Ontology · 11
- GO:0030288 outer membrane-bounded periplasmic space
- GO:0005886 plasma membrane
- GO:0004180 carboxypeptidase activity
- GO:0008658 penicillin binding
- GO:0042803 protein homodimerization activity
- GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
- GO:0071555 cell wall organization
- GO:0009252 peptidoglycan biosynthetic process
- GO:0006508 proteolysis
- GO:0008360 regulation of cell shape
- GO:0009410 response to xenobiotic stimulus
Drugs targeting this protein · 85
- CEFOTAXIME SODIUM inhibitor
- AMOXICILLIN inhibitor
- CEFUROXIME AXETIL inhibitor
- PENICILLIN G SODIUM inhibitor
- CEFAMANDOLE inhibitor
- CYCLACILLIN inhibitor
- MOXALACTAM DISODIUM inhibitor
- CEPHALEXIN HYDROCHLORIDE inhibitor
- CEFOPERAZONE SODIUM inhibitor
- CEFAZOLIN SODIUM inhibitor
- CEFOXITIN SODIUM inhibitor
- CEPHALEXIN inhibitor
- LORACARBEF inhibitor
- CEFPIRAMIDE SODIUM inhibitor
- AMPICILLIN SODIUM inhibitor
- CEFTAZIDIME SODIUM inhibitor
- PIPERACILLIN SODIUM inhibitor
- PENICILLIN V POTASSIUM inhibitor
- TICARCILLIN DISODIUM inhibitor
- CEFEPIME HYDROCHLORIDE inhibitor
- BACAMPICILLIN HYDROCHLORIDE inhibitor
- CEPHALOGLYCIN inhibitor
- CEFTIBUTEN DIHYDRATE inhibitor
- CARBENICILLIN INDANYL SODIUM inhibitor
- CEFONICID SODIUM inhibitor
- CEFPODOXIME PROXETIL inhibitor
- CEFACLOR inhibitor
- CEFTIZOXIME SODIUM inhibitor
- CEPHAPIRIN SODIUM inhibitor
- CEFORANIDE inhibitor
- CEFOTETAN DISODIUM inhibitor
- CEFMETAZOLE SODIUM inhibitor
- CEFTOLOZANE SULFATE inhibitor
- PENICILLIN G POTASSIUM inhibitor
- ERTAPENEM SODIUM inhibitor
- RAZUPENEM inhibitor
- FAROPENEM MEDOXOMIL inhibitor
- MEROPENEM inhibitor
- TEMOCILLIN inhibitor
- ERTAPENEM inhibitor
- CEFIXIME inhibitor
- FLOMOXEF inhibitor
- AZTREONAM inhibitor
- CEPHRADINE inhibitor
- CEFTIBUTEN inhibitor
- PHENETHICILLIN inhibitor
- CEFAMANDOLE NAFATE inhibitor
- TALAMPICILLIN inhibitor
- CEPHALOTHIN SODIUM inhibitor
- CEFADROXIL inhibitor
- CEFPODOXIME inhibitor
- MEZLOCILLIN SODIUM inhibitor
- AMPICILLIN inhibitor
- SULOPENEM inhibitor
- PENAMECILLIN inhibitor
- TEBIPENEM PIVOXIL inhibitor
- CEFUROXIME SODIUM inhibitor
- FLOXACILLIN inhibitor
- CEFTIOFUR inhibitor
- CEFODIZIME inhibitor
- PIVAMPICILLIN inhibitor
- CEFMENOXIME HYDROCHLORIDE inhibitor
- CEFSULODIN inhibitor
- CEFTAROLINE FOSAMIL ACETATE inhibitor
- AZTREONAM LYSINE inhibitor
- PENICILLIN G BENZATHINE inhibitor
- CEFIDEROCOL inhibitor
- CEFIDEROCOL SULFATE TOSYLATE inhibitor
- CEFILAVANCIN inhibitor
- CEFOTIAM HYDROCHLORIDE inhibitor
- DORIPENEM MONOHYDRATE inhibitor
- IMIPENEM inhibitor
- CEFTAZIDIME inhibitor
- CEFDITOREN PIVOXIL inhibitor
- SULOPENEM ETZADROXIL inhibitor
- DORIPENEM inhibitor
- CEFTAROLINE FOSAMIL inhibitor
- CEFTOBIPROLE inhibitor
- CEFPROZIL, (E)- inhibitor
- FAROPENEM inhibitor
- CARBENICILLIN DISODIUM inhibitor
- CEFTRIAXONE SODIUM inhibitor
- PENICILLIN V inhibitor
- CEFPIROME inhibitor
- CEFDINIR inhibitor
Related proteins · sequence + function similarity
- D-alanyl-D-alanine carboxypeptidase DacA 0.92
- D-alanyl-D-alanine carboxypeptidase DacA 0.92
- D-alanyl-D-alanine carboxypeptidase DacA 0.92
- D-alanyl-D-alanine carboxypeptidase DacA 0.90
- D-alanyl-D-alanine carboxypeptidase DacD 0.75
- D-alanyl-D-alanine carboxypeptidase DacD 0.72
- D-alanyl-D-alanine endopeptidase 0.69
- D-alanyl-D-alanine endopeptidase 0.69
- Beta-lactamase OXY-2 0.66
- Beta-lactamase CTX-M-8 0.66
- D-alanyl-D-alanine endopeptidase 0.66
- Beta-lactamase OXY-1 0.66
Co-cited proteins · studied together in the literature
- D-alanyl-D-alanine carboxypeptidase DacA 2 shared papers
Literature · 6 cited papers
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- The complete genome sequence of Escherichia coli K-12. Science · 1997
- A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. DNA Res. · 1996
- Amino acid sequence homologies between Escherichia coli penicillin-binding protein 5 and class A beta-lactamases. FEBS Lett. · 1982
- An 18 amino acid amphiphilic helix forms the membrane-anchoring domain of the Escherichia coli penicillin-binding protein 5. Mol. Microbiol. · 1987
- Nucleotide sequences of the penicillin-binding protein 5 and 6 genes of Escherichia coli. Nucleic Acids Res. · 1988
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