DNA polymerase catalytic subunit
Function
Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication.
Classification
- Family (Pfam)
- PF00136 DNA_pol_B, PF03104 DNA_pol_B_exo1, PF11590 DNAPolymera_Pol
- InterPro
- DNA-dir_DNA_pol_B, DNA-dir_DNA_pol_B_CS, DNA-dir_DNA_pol_B_exonuc, DNA-dir_DNA_pol_B_multi_dom, DNA/RNA_pol_sf, DNA_pol_B_thumb, DNA_pol_palm_dom_sf, DNA_pol_type-B, DNAPolymera_Pol_C, RNaseH-like_sf, RNaseH_sf
- Functional cluster
- Viral Structural & Chromatin Proteins
Experimental structures · PDB · 9
- 7LUF X-ray 3.50A
- 8OJ6 EM 2.41A
- 8OJ7 EM 2.46A
- 8OJA EM 1.87A
- 8OJB EM 1.90A
- 8OJC EM 2.08A
- 8OJD EM 2.46A
- 9ENP EM 2.12A
- 9ENQ EM 2.12A
A predicted model is available from AlphaFold.
Gene Ontology · 10
- GO:0042575 DNA polymerase complex
- GO:0042025 host cell nucleus
- GO:0008409 5'-3' exonuclease activity
- GO:0003677 DNA binding
- GO:0034061 DNA polymerase activity
- GO:0003887 DNA-directed DNA polymerase activity
- GO:0000166 nucleotide binding
- GO:0004523 RNA-DNA hybrid ribonuclease activity
- GO:0039686 bidirectional double-stranded viral DNA replication
- GO:0006261 DNA-templated DNA replication
Drugs targeting this protein · 12
- VIDARABINE inhibitor
- ACYCLOVIR SODIUM inhibitor
- VALGANCICLOVIR HYDROCHLORIDE inhibitor
- GANCICLOVIR SODIUM inhibitor
- VALACYCLOVIR HYDROCHLORIDE inhibitor
- PENCICLOVIR inhibitor
- GANCICLOVIR inhibitor
- ACYCLOVIR inhibitor
- PENCICLOVIR SODIUM inhibitor
- CIDOFOVIR inhibitor
- FOSCARNET SODIUM inhibitor
- FAMCICLOVIR inhibitor
Related proteins · sequence + function similarity
- DNA polymerase catalytic subunit 1.00
- DNA polymerase catalytic subunit 1.00
- DNA polymerase catalytic subunit 1.00
- DNA polymerase catalytic subunit 0.99
- DNA polymerase catalytic subunit 0.98
- DNA polymerase catalytic subunit 0.91
- DNA polymerase catalytic subunit 0.90
- DNA polymerase catalytic subunit 0.90
- DNA polymerase catalytic subunit 0.87
- DNA polymerase catalytic subunit 0.86
- DNA polymerase catalytic subunit 0.86
- DNA polymerase catalytic subunit 0.86
Co-cited proteins · studied together in the literature
- DNA helicase/primase complex-associated protein 1 shared papers
- Major DNA-binding protein 1 shared papers
Literature · 5 cited papers
- Determination and analysis of the DNA sequence of highly attenuated herpes simplex virus type 1 mutant HF10, a potential oncolytic virus. Microbes Infect. · 2007
- The catalytic subunit of the DNA polymerase of herpes simplex virus type 1 interacts specifically with the C terminus of the UL8 component of the viral helicase-primase complex. J. Virol. · 1997
- DNA sequence of the region in the genome of herpes simplex virus type 1 containing the genes for DNA polymerase and the major DNA binding protein. Nucleic Acids Res. · 1985
- The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. · 1988
- Herpes simplex-1 DNA polymerase. Identification of an intrinsic 5'----3' exonuclease with ribonuclease H activity. J. Biol. Chem. · 1989
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.