DNA polymerase catalytic subunit
Function
Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).
Classification
- Family (Pfam)
- PF00136 DNA_pol_B, PF03104 DNA_pol_B_exo1, PF11590 DNAPolymera_Pol
- InterPro
- DNA-dir_DNA_pol_B, DNA-dir_DNA_pol_B_CS, DNA-dir_DNA_pol_B_exonuc, DNA-dir_DNA_pol_B_multi_dom, DNA/RNA_pol_sf, DNA_pol_B_thumb, DNA_pol_palm_dom_sf, DNA_pol_type-B, DNAPolymera_Pol_C, RNaseH-like_sf, RNaseH_sf
- Functional cluster
- Viral Structural & Chromatin Proteins
Experimental structures · PDB · 1
- 2GV9 X-ray 2.68A
A predicted model is available from AlphaFold.
Gene Ontology · 8
- GO:0042025 host cell nucleus
- GO:0003677 DNA binding
- GO:0003887 DNA-directed DNA polymerase activity
- GO:0004527 exonuclease activity
- GO:0000166 nucleotide binding
- GO:0004523 RNA-DNA hybrid ribonuclease activity
- GO:0039686 bidirectional double-stranded viral DNA replication
- GO:0006261 DNA-templated DNA replication
Drugs targeting this protein · 1
- SORIVUDINE inhibitor
Related proteins · sequence + function similarity
- DNA polymerase catalytic subunit 1.00
- DNA polymerase catalytic subunit 1.00
- DNA polymerase catalytic subunit 1.00
- DNA polymerase catalytic subunit 0.98
- DNA polymerase catalytic subunit 0.98
- DNA polymerase catalytic subunit 0.90
- DNA polymerase catalytic subunit 0.90
- DNA polymerase catalytic subunit 0.90
- DNA polymerase catalytic subunit 0.86
- DNA polymerase catalytic subunit 0.86
- DNA polymerase catalytic subunit 0.86
- DNA polymerase catalytic subunit 0.86
Literature · 2 cited papers
- A point mutation in a herpesvirus polymerase determines neuropathogenicity. PLoS Pathog. · 2007
- Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain. Proc. Natl. Acad. Sci. U.S.A. · 1985
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