Plasma kallikrein

UniProt P03952 Organism Homo sapiens Gene KLK3, KLKB1 EC 3.4.21.34

Also known as: KLK3, KLKB1

Function

Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Classification

Family (Pfam): PF00024 PAN_1, PF00089 Trypsin
InterPro: Apple, Pan_app, Peptidase_S1_PA, Peptidase_S1_PA_chymotrypsin, Peptidase_S1A, Trypsin_dom, TRYPSIN_HIS, TRYPSIN_SER
Functional cluster: Venom Serine Proteases & Phospholipase A2

Experimental structures · PDB · 17

2ANW X-ray 1.85A
2ANY X-ray 1.40A
4OGX X-ray 2.40A
4OGY X-ray 2.10A
5F8T X-ray 1.75A
5F8X X-ray 1.55A
5F8Z X-ray 1.50A
5TJX X-ray 1.41A
6I44 X-ray 1.36A
6O1G X-ray 2.20A
6O1S X-ray 1.70A
6T7P X-ray 1.42A
… and 5 more

A predicted model is available from AlphaFold.

Gene Ontology · 13

Disease associations

inherited prekallikrein deficiency MONDO:0012901

Drugs targeting this protein · 2

AVORALSTAT inhibitor
BEROTRALSTAT HYDROCHLORIDE inhibitor

Related proteins · sequence + function similarity

Plasma kallikrein 0.98
Plasma kallikrein 0.98
Plasma kallikrein 0.97
Coagulation factor XI 0.96
Coagulation factor XI 0.96
Coagulation factor XI 0.95
Transmembrane protease serine 7 0.80
Tissue-type plasminogen activator 0.79
Transmembrane protease serine 7 0.79
Tissue-type plasminogen activator 0.79
Tissue-type plasminogen activator 0.79
Salivary plasminogen activator alpha 2 0.79

Co-cited proteins · studied together in the literature

Iripin-3 1 shared papers
Suppressor of tumorigenicity 14 protein 2 shared papers
Iripin-1 1 shared papers
Coagulation factor XI 1 shared papers
Coagulation factor V 1 shared papers
Plasma serine protease inhibitor 1 shared papers
Prothrombin 1 shared papers
Plasminogen 1 shared papers

Literature · 15 cited papers

Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment <i>in vivo</i> while altering the levels of chemokines and adhesion molecules. Front. Immunol. · 2023
Prekallikrein deficiency due to homozygous KLKB1(+) mutation c.444_445insT (p.Ser151PhefsTer34). Int. J. Lab. Hematol. · 2022
Iripin-3, a New Salivary Protein Isolated From Ixodes ricinus Ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In Vitro. Front. Immunol. · 2021
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
A new type of plasma prekallikrein deficiency associated with homozygosity for Gly104Arg and Asn124Ser in apple domain 2 of the heavy-chain region. Eur. J. Haematol. · 2007
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J. Proteome Res. · 2005
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Severe prekallikrein (Fletcher factor) deficiency due to a compound heterozygosis (383Trp stop codon and Cys529Tyr). Thromb. Haemost. · 2003
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. Nat. Biotechnol. · 2003
Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease. Genomics · 2000
… and 3 more in the literature graph

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.