NADH-ubiquinone oxidoreductase chain 2

UniProt P03891 Organism Homo sapiens Gene MT-ND2, MTND2, NADH2, ND2 EC 7.1.1.2

Also known as: MT-ND2, MTND2, NADH2, ND2

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Classification

Family (Pfam): PF06444 NADH_dehy_S2_C, PF00361 Proton_antipo_M
InterPro: Complex_I_Subunit_2, NADH_DH_su2_C, NADH_UbQ_OxRdtase_chain2, ND/Mrp_TM
Functional cluster: Cytochrome b & NADH Dehydrogenase Subunits

Experimental structures · PDB · 7

5XTC EM 3.70A
5XTD EM 3.70A
5XTH EM 3.90A
5XTI EM 17.40A
9CWT EM 3.44A
9I4I EM 2.63A
9TI4 EM 2.66A

A predicted model is available from AlphaFold.

Gene Ontology · 11

Disease associations

Leigh syndrome MONDO:0009723
Alzheimer disease, susceptibility to, mitochondrial MONDO:0100295
Leber hereditary optic neuropathy MONDO:0010788

Drugs targeting this protein · 2

METFORMIN HYDROCHLORIDE inhibitor
ME-344 inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

NADH-ubiquinone oxidoreductase chain 2 1 shared papers
NADH-ubiquinone oxidoreductase chain 5 10 shared papers
NADH-ubiquinone oxidoreductase chain 1 9 shared papers
Cytochrome c oxidase subunit 1 7 shared papers
NADH-ubiquinone oxidoreductase chain 3 8 shared papers
Cytochrome b 4 shared papers
ATP synthase F(0) complex subunit 8 7 shared papers
NADH-ubiquinone oxidoreductase chain 4L 7 shared papers
ATP synthase F(0) complex subunit a 7 shared papers
NADH-ubiquinone oxidoreductase chain 4 7 shared papers
NADH-ubiquinone oxidoreductase chain 6 6 shared papers
Cytochrome c oxidase subunit 3 3 shared papers

Literature · 19 cited papers

TMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase and interact with assembly factors for complex I. Proc. Natl. Acad. Sci. U.S.A. · 2021
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
Mutated ND2 impairs mitochondrial complex I assembly and leads to Leigh syndrome. Mol. Genet. Metab. · 2007
Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians. Int. J. Legal Med. · 2004
Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J. Mol. Biol. Evol. · 2003
Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines. Genome Res. · 2003
The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
Mitochondrial genome variation and the origin of modern humans. Nature · 2000
Departure from neutrality at the mitochondrial NADH dehydrogenase subunit 2 gene in humans, but not in chimpanzees. Genetics · 1998
Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome. Nucleic Acids Res. · 1998
Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs. Proc. Natl. Acad. Sci. U.S.A. · 1995
… and 7 more in the literature graph

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