Fusion glycoprotein F0

Function

Inactive precursor that is cleaved at two sites by a furin-like protease to give rise to the mature F1 and F2 fusion glycoproteins.

Classification

Family (Pfam)

PF00523 Fusion_gly

InterPro

Fusion_F0_Paramyxovir

Functional cluster

Cell-Wall Polysaccharide Hydrolases

Experimental structures · PDB · 82

• 2MDP NMR
• 3IXT X-ray 2.75A
• 3KPE X-ray 1.47A
• 3O41 X-ray 1.95A
• 3O45 X-ray 2.87A
• 3RKI X-ray 3.20A
• 3RRR X-ray 2.82A
• 3RRT X-ray 3.20A
• 4CCF X-ray 2.65A
• 4JHW X-ray 3.60A
• 4MMQ X-ray 3.25A
• 4MMR X-ray 3.10A
• … and 70 more

A predicted model is available from AlphaFold.

Gene Ontology · 10

• GO:0044178 host cell Golgi membrane
• GO:0020002 host cell plasma membrane
• GO:0005886 plasma membrane
• GO:0019031 viral envelope
• GO:0055036 virion membrane
• GO:0042802 identical protein binding
• GO:0098670 entry receptor-mediated virion attachment to host cell
• GO:0019064 fusion of virus membrane with host plasma membrane
• GO:0046718 symbiont entry into host cell
• GO:0060141 symbiont-mediated induction of syncytium formation

Drugs targeting this protein · 1

• PRESATOVIR inhibitor

Related proteins · sequence + function similarity

• Fusion glycoprotein F0 1.00
• Fusion glycoprotein F0 1.00
• Fusion glycoprotein F0 0.99
• Fusion glycoprotein F0 0.99
• Fusion glycoprotein F0 0.98
• Fusion glycoprotein F0 0.98
• Fusion glycoprotein F0 0.98
• Fusion glycoprotein F0 0.92
• Fusion glycoprotein F0 0.91
• Fusion glycoprotein F0 0.90
• Fusion glycoprotein F0 0.90
• Fusion glycoprotein F0 0.89

Co-cited proteins · studied together in the literature

• Fusion glycoprotein F0 1 shared papers
• Major surface glycoprotein G 5 shared papers
• Protein M2-1 4 shared papers
• Small hydrophobic protein 3 shared papers
• Protein M2-2 4 shared papers
• Insulin-like growth factor 1 receptor 1 shared papers
• RNA-directed RNA polymerase L 4 shared papers
• Transforming protein RhoA 1 shared papers
• Nucleoprotein 4 shared papers
• Phosphoprotein 4 shared papers
• Matrix protein 3 shared papers
• Non-structural protein 2 3 shared papers

Literature · 45 cited papers

• IGF1R is an entry receptor for respiratory syncytial virus. Nature · 2020
• A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein. Nat. Commun. · 2019
• Alternative conformations of a major antigenic site on RSV F. PLoS Pathog. · 2019
• Dual Inhibition of Human Parainfluenza Type 3 and Respiratory Syncytial Virus Infectivity with a Single Agent. J. Am. Chem. Soc. · 2019
• Transient opening of trimeric prefusion RSV F proteins. Nat. Commun. · 2019
• Structure basis of neutralization by a novel site II/IV antibody against respiratory syncytial virus fusion protein. PLoS ONE · 2019
• Respiratory syncytial virus entry and how to block it. Nat. Rev. Microbiol. · 2019
• Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation. Immunity · 2018
• The Heptad Repeat C Domain of the Respiratory Syncytial Virus Fusion Protein Plays a Key Role in Membrane Fusion. J. Virol. · 2018
• Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein. Nat. Commun. · 2017
• Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nat. Commun. · 2017
• A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants. Sci. Transl. Med. · 2017
• … and 33 more in the literature graph