Transthyretin

Function

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Classification

Family (Pfam)

PF00576 Transthyretin

InterPro

Thyroxine_BS, Transthyretin/HIU_hydrolase, Transthyretin/HIU_hydrolase_d, Transthyretin/HIU_hydrolase_sf, Transthyretin_CS

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 448

• 1BM7 X-ray 2.00A
• 1BMZ X-ray 2.00A
• 1BZ8 X-ray 2.00A
• 1BZD X-ray 1.90A
• 1BZE X-ray 1.80A
• 1DVQ X-ray 2.00A
• 1DVS X-ray 2.00A
• 1DVT X-ray 1.90A
• 1DVU X-ray 1.90A
• 1DVX X-ray 2.00A
• 1DVY X-ray 1.90A
• 1DVZ X-ray 1.90A
• … and 436 more

A predicted model is available from AlphaFold.

Gene Ontology · 12

• GO:0035578 azurophil granule lumen
• GO:0070062 extracellular exosome
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0032991 protein-containing complex
• GO:0005179 hormone activity
• GO:0042562 hormone binding
• GO:0042802 identical protein binding
• GO:0140313 molecular sequestering activity
• GO:0044877 protein-containing complex binding
• GO:0006144 purine nucleobase metabolic process
• GO:0001523 retinoid metabolic process

Disease associations

• amyloidosis, hereditary systemic 1 MONDO:0971004
• carpal tunnel syndrome 1 MONDO:0020730
• hyperthyroxinemia, dystransthyretinemic MONDO:0007785

Drugs targeting this protein · 4

• TAFAMIDIS stabiliser
• TAFAMIDIS MEGLUMINE stabiliser
• ACORAMIDIS stabiliser
• ACORAMIDIS HYDROCHLORIDE stabiliser

Related proteins · sequence + function similarity

• Transthyretin 0.99
• Transthyretin 0.99
• Transthyretin 0.98
• Transthyretin 0.97
• Transthyretin 0.96
• Transthyretin 0.95
• Transthyretin 0.95
• Transthyretin 0.95
• Transthyretin 0.95
• Transthyretin 0.94
• Transthyretin 0.94
• Transthyretin 0.94

Co-cited proteins · studied together in the literature

• Retinol-binding protein 4 3 shared papers
• Apolipoprotein A-I 1 shared papers
• Dipeptidyl peptidase 1 1 shared papers
• Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 1 shared papers
• Coagulation factor VII 1 shared papers
• Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 shared papers
• Prosaposin 1 shared papers

Literature · 126 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Delayed diagnosis of transthyretin amyloidosis with a novel mutation (c.210T>A) in the transthyretin gene. J. Am. Acad. Dermatol. · 2013
• Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. Cell · 2009
• Structural and mutational analyses of protein-protein interactions between transthyretin and retinol-binding protein. FEBS J. · 2008
• Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J. Med. Chem. · 2008
• Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. J. Mol. Biol. · 2008
• Detection of a gamma-carboxy-glutamate as novel post-translational modification of human transthyretin. Protein Pept. Lett. · 2008
• Iodination of salicylic acid improves its binding to transthyretin. Biochim. Biophys. Acta · 2008
• Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. J. Med. Chem. · 2008
• Familial amyloidosis in a large Spanish kindred resulting from a D38V mutation in the transthyretin gene. Eur. J. Clin. Invest. · 2007
• A novel type of familial transthyretin amyloidosis, ATTR Asn124Ser, with co-localization of kappa light chains. Amyloid · 2007
• Genetic microheterogeneity of human transthyretin detected by IEF. Electrophoresis · 2007
• … and 114 more in the literature graph