Coagulation factor VII

UniProt P08709 Organism Homo sapiens Gene F7 EC 3.4.21.21

Also known as: F7

Function

Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium.

Classification

Family (Pfam): PF00008 EGF, PF14670 FXa_inhibition, PF00594 Gla, PF00089 Trypsin
InterPro: Coagulation_fac-like_Gla_dom, EGF, EGF-like_Ca-bd_dom, EGF-type_Asp/Asn_hydroxyl_site, EGF_Ca-bd_CS, GLA-like_dom_SF, GLA_domain, Pept_S1A_FX, Peptidase_S1_coag_factors, Peptidase_S1_PA, Peptidase_S1_PA_chymotrypsin, Peptidase_S1A, Trypsin_dom, TRYPSIN_HIS, TRYPSIN_SER
Functional cluster: Venom Serine Proteases & Phospholipase A2

Experimental structures · PDB · 113

1BF9 NMR
1CVW X-ray 2.28A
1DAN X-ray 2.00A
1DVA X-ray 3.00A
1F7E NMR
1F7M NMR
1FAK X-ray 2.10A
1FF7 NMR
1FFM NMR
1J9C X-ray 2.90A
1JBU X-ray 2.00A
1KLI X-ray 1.69A
… and 101 more

A predicted model is available from AlphaFold.

Gene Ontology · 35

Disease associations

congenital factor VII deficiency MONDO:0009211

Drugs targeting this protein · 1

PCI-27483 inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Tissue factor 3 shared papers
Coagulation factor VII 1 shared papers
Coagulation factor VII 1 shared papers
Coagulation factor IX 4 shared papers
Vitamin K-dependent protein Z 2 shared papers
GDP-fucose protein O-fucosyltransferase 1 1 shared papers
Vitamin K-dependent protein Z 2 shared papers
GDP-fucose protein O-fucosyltransferase 1 1 shared papers
Protein O-glucosyltransferase 1 1 shared papers
Dipeptidyl peptidase 1 1 shared papers
Protein O-glucosyltransferase 1 1 shared papers
Coagulation factor VII 1 shared papers

Literature · 48 cited papers

Structural and functional characterization of novel F7 mutations identified in Chinese factor VII-deficient patients. Br. J. Haematol. · 2023
Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement. Int. J. Mol. Sci. · 2021
Severe coagulation factor VII deficiency caused by a novel homozygous mutation (p. Trp284Gly) in loop 140s. Blood Coagul. Fibrinolysis · 2016
Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Proc. Natl. Acad. Sci. U.S.A. · 2011
A novel missense mutation close to the charge-stabilizing system in a patient with congenital factor VII deficiency. Blood Coagul. Fibrinolysis · 2011
Recurrent mutations and genotype-phenotype correlations in hereditary factor VII deficiency in Korea. Blood Coagul. Fibrinolysis · 2011
Phenotypic and genotypic characterization of Factor VII deficiency patients from Western India. Clin. Chim. Acta · 2009
Familial factor VII deficiency with foetal and neonatal fatal cerebral haemorrhage associated with homozygosis to Gly180Arg mutation. Haemophilia · 2009
Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms. Cell · 2009
Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene. Haemophilia · 2009
Human F7 sequence is split into three deep clades that are related to FVII plasma levels. Hum. Genet. · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
… and 36 more in the literature graph

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