High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland.

Classification

Family (Pfam)

PF13426 PAS_9, PF08629 PDE8, PF28324 PDE8_3rd, PF23198 PDE8A_N, PF00233 PDEase_I

InterPro

HD/PDEase_dom, PAS, PAS-like_dom_sf, PDE8-like_REC_N, PDEase, PDEase_catalytic_dom, PDEase_catalytic_dom_sf, PDEase_CS

Functional cluster

Zinc-Finger Nucleic-Acid-Binding & Methyltransferases

Gene Ontology · 9

• GO:0005829 cytosol
• GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
• GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
• GO:0046872 metal ion binding
• GO:0006198 cAMP catabolic process
• GO:0141162 negative regulation of cAMP/PKA signal transduction
• GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
• GO:0070374 positive regulation of ERK1 and ERK2 cascade
• GO:0007165 signal transduction

Disease associations

• autosomal dominant striatal neurodegeneration type 1 MONDO:0012205
• pigmented nodular adrenocortical disease, primary, 3 MONDO:0013616

Drugs targeting this protein · 3

• FLAVOXATE HYDROCHLORIDE inhibitor
• PENTOXIFYLLINE inhibitor
• DIPYRIDAMOLE inhibitor

Related proteins · sequence + function similarity

• High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B 0.99
• High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 0.92
• High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A 0.92
• Probable 3',5'-cyclic phosphodiesterase pde-6 0.80
• Probable 3',5'-cyclic phosphodiesterase pde-2 0.76
• High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 0.76
• Probable 3',5'-cyclic phosphodiesterase pde-1 0.72
• Probable 3',5'-cyclic-AMP phosphodiesterase pde-4 0.71
• 3',5'-cyclic-AMP phosphodiesterase 4B 0.70
• 3',5'-cyclic-AMP phosphodiesterase 4B 0.69
• 3',5'-cyclic-AMP phosphodiesterase 4D 0.69
• Probable 3',5'-cyclic phosphodiesterase pde-3 0.68

Co-cited proteins · studied together in the literature

• High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B 1 shared papers

Literature · 10 cited papers

• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Autosomal-dominant striatal degeneration is caused by a mutation in the phosphodiesterase 8B gene. Am. J. Hum. Genet. · 2010
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex. Eur. J. Hum. Genet. · 2008
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans. Cell. Signal. · 2003
• Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene. Biochem. Biophys. Res. Commun. · 2002
• Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase. Biochem. Biophys. Res. Commun. · 1998