Xaa-Pro aminopeptidase 2

UniProt O43895 Organism Homo sapiens Gene XPNPEP2 EC 3.4.11.9

Also known as: XPNPEP2

Function

Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.

Classification

Family (Pfam): PF01321 Creatinase_N, PF16189 Creatinase_N_2, PF00557 Peptidase_M24, PF16188 Peptidase_M24_C
InterPro: Creatin/AminoP/Spt16_N, Creatinase/aminopeptidase-like, Creatinase_N, Pept_M24, Pept_M24B, Peptidase_M24_C, Peptidase_M24B_aminopep-P_CS, X-Pro_aminopeptidase_P
Functional cluster: Secreted Hydrolases & Toxins

Gene Ontology · 9

Disease associations

susceptibility to angioedema induced by ACE inhibitors MONDO:0100003

Drugs targeting this protein · 1

TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

Literature · 7 cited papers

A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema. Hum. Mutat. · 2011
Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenet. Genomics · 2010
A variant in XPNPEP2 is associated with angioedema induced by angiotensin I-converting enzyme inhibitors. Am. J. Hum. Genet. · 2005
The DNA sequence of the human X chromosome. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates. Biochem. J. · 2005
Cloning and tissue distribution of human membrane-bound aminopeptidase P. Biochim. Biophys. Acta · 1997

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