Xaa-Pro aminopeptidase 1

Function

Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Contributes to the degradation of bradykinin.

Classification

Family (Pfam)

PF01321 Creatinase_N, PF16189 Creatinase_N_2, PF00557 Peptidase_M24, PF16188 Peptidase_M24_C

InterPro

Creatin/AminoP/Spt16_N, Creatinase/aminopeptidase-like, Creatinase_N, Pept_M24, Pept_M24B, Peptidase_M24_C, Peptidase_M24B_aminopep-P_CS, X-Pro_aminopeptidase_P

Functional cluster

Oxidoreductases & Polyketide Synthases

Experimental structures · PDB · 1

• 3CTZ X-ray 1.60A

A predicted model is available from AlphaFold.

Gene Ontology · 10

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0004177 aminopeptidase activity
• GO:0030145 manganese ion binding
• GO:0070006 metalloaminopeptidase activity
• GO:0042803 protein homodimerization activity
• GO:0010815 bradykinin catabolic process
• GO:0043069 negative regulation of programmed cell death
• GO:0006508 proteolysis

Drugs targeting this protein · 1

• TOSEDOSTAT inhibitor

Related proteins · sequence + function similarity

• Xaa-Pro aminopeptidase 1 1.00
• Xaa-Pro aminopeptidase 1 1.00
• Xaa-Pro aminopeptidase 1 0.99
• Probable Xaa-Pro aminopeptidase P 0.91
• Uncharacterized peptidase C22G7.01c 0.89
• Probable Xaa-Pro aminopeptidase P 0.88
• Xaa-Pro aminopeptidase app-1 0.88
• Probable Xaa-Pro aminopeptidase P 0.88
• Probable Xaa-Pro aminopeptidase P 0.87
• Probable Xaa-Pro aminopeptidase P 0.87
• Probable Xaa-Pro aminopeptidase P 0.87
• Aminopeptidase P1 0.87

Co-cited proteins · studied together in the literature

• Xaa-Pro dipeptidase 1 shared papers
• Caspase recruitment domain-containing protein 8 1 shared papers

Literature · 14 cited papers

• M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome. Nat. Chem. Biol. · 2022
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit. J. Biol. Chem. · 2008
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and comparative analysis of human chromosome 10. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat. Biotechnol. · 2003
• Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme. Biochemistry · 2000
• … and 2 more in the literature graph