Nirogacestat
SMILES CCC[C@H](N[C@H]1CCc2cc(F)cc(F)c2C1)C(=O)Nc1cn(C(C)(C)CNCC(C)(C)C)cn1
Structure
2D skeletal formula · rendered by chemkit from PubChem 2D coordinates.
Pseudo-3D ball-and-stick · chemkit, from PubChem 3D conformer coordinates.
Protein targets · 6 targets
- Gamma-secretase subunit APH-1A Q96BI3 · inhibitor · Gamma-secretase inhibitor
- Gamma-secretase subunit PEN-2 Q9NZ42 · inhibitor · Gamma-secretase inhibitor
- Gamma-secretase subunit APH-1B Q8WW43 · inhibitor · Gamma-secretase inhibitor
- Presenilin-1 P49768 · inhibitor · Gamma-secretase inhibitor
- Nicastrin Q92542 · inhibitor · Gamma-secretase inhibitor
- Presenilin-2 P49810 · inhibitor · Gamma-secretase inhibitor
Each resolved target links to its lmmol protein document; action and mechanism are from the bioactivity record.
A document in the lmmol reference corpus — a real compound (PubChem / ChEMBL identity, chemkit-rendered structure) cross-linked to the protein documents it targets. Hover any link to preview its target.